Relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ

Faraj Ali Aldaefi Mohamed; Adji Tjahjono Harjoedi

doi:10.30574/gscbps.2020.11.1.0032

Authors

Faraj Ali Aldaefi Mohamed Master program of Biomedical Sciences Faculty of Medicine, Universitas Brawijaya, Malang 65145 Indonesia.
Adji Tjahjono Harjoedi Pediatric department, Saiful Anwar General Hospital Malang 65112 Indonesia.

DOI:

https://doi.org/10.30574/gscbps.2020.11.1.0032

Keywords:

Vitamin D deficiency, Type 1 DM, cIMT, FMD%

Abstract

Vitamin D deficiency has been related to increased risk of myocardial infarction, stroke. Type 1 DM patients have a higher risk of atherosclerosis, which is the leading cause of death in most patients, and IFN-γ is a pro inflammatory cytokine, and type 1 DM is a chronic inflammation. In our study, we try to detect the premature atherosclerosis in adolescents with type 1 DM who have vitamin D deficiency through inflammatory IFN-γ.

The study is a case control with 31 diabetic children aged 6 to 18 years as a case group, and control group 35 healthy children aged 10-18 years. We analysis the vitamin D, IFN- and ,HbA1c, and using Doppler US for cIMT of common carotid artery(CCA), and flow mediated dilation index(FMD%) of the brachial artery. And analysis the data through SPSS version16.0.

Type 1 DM group have higher levels of IFN-γ (p-0.005) and cIMT (p-0.01.) and both were significant, while the correlation effect of vitamin D deficiency and IFN-γ on both cIMT and FMD% were (p-0.294) and (p-0.270) (p-0.794)and (p-0.894) respectively and both insignificant, and correlation effect of HbA1c on cIMT was significant with (p-0.002), and correlation effect of HbA1c on FMD% was insignificant with (p-0.222).

We concluded that there is significantly higher of IFN-γ in type 1 DM, also a significant correlation effect of HbA1c on cIMT, and no relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ.

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