Formulation and characterization of papaya leaf gel
DOI:
https://doi.org/10.30574/gscbps.2020.10.3.0054Keywords:
Papaya leaf gel, Carbopol 934, Ethanolic extraction, Dermal preparationAbstract
The study was designed for ethanolic extraction of papaya leaf, phytochemical screening of the extract, formulation of papaya leaf gel by using carbopol 934 and characterization of the herbal gel. The fresh papaya leaves were collected and extracted by maceration process using ethanol as a solvent. The extract was analysed by UV spectrophotometer and IR spectroscopy for identification of phytochemical compounds. Then the phytochemical evaluation was performed and the presence of glycoside, tannins, flavonoids and saponins were observed. The herbal gel was prepared by using carbopol 934 polymer and isopropyl alcohol as penetration enhancer. pH of 6 was observed by using the pH meter. Swelling index of blank gel was 190% and the swelling index of herbal gel was 220%. In the spreadability study, the diameter of the spot was observed within 3.5-3.7 cm. The interaction study between phytochemicals and the excipients was carried out by FTIR spectroscopy.
Metrics
References
Sherwood L.(2007). Human Physiology, 6th Edition. From cells to systems, Thomson Brooks, Stamford.
Noble WC. (1993).The skin microflora and microbial skin disease.University of Cambridge, Cambridge.
Mackie RM. (2002). Clinical dermatology, 5th Edition. Oxford University Press, Oxford.
El Maghraby GM, Barry BW and Williams AC. (2008). Liposomes and skin: From drug delivery to model membranes. European Journal of Pharmaceutical Sciences, 34, 203-222.
Nino M, Calabro G andSantoianni P. (2010). Topical delivery of active principles: The field of dermatological research. Dermatology online Journal, 16(4).
Kaur LP and Guleri TK. (2013).Topical Gel: A Recent Approach for Novel Drug delivery. Asian Journal of Biomedical& Pharmaceutical Science, 3(17), 1-5.
Herbaria plants. (1985). e-Monograph of Caricaceae.
Elgadir MA and Adam A. (2013). An in vitro evaluation of films prepared from gelatin Carica papaya methanolic extract for wound healing. International Journal of Drug Delivery, 5, 233-238.
Alabi OA, Haruna MT, Anokwuru CP, Jegede T, Abia H, Okegbe VU and Babatunde EE. (2012). Comparative studies on antimicrobial properties of extracts of fresh and dried leaves of carica papaya (L) on clinical bacterial and fungalisolates. Advances in Applied Science Research, 3(5), 3107-3114.
IkeyiAdachukwu P, Ogbonna Ann O and Eze FU. (2013). Phytochemical analysis of paw-paw (Carica papaya) leaves. International Journal of Life Sciences Biotechnology Pharma Research, 2(3), 347-351.
Patel J, Patel B, Banwait HS, Parmar K and Patel M. (2011). Formulation and evaluation of topical aceclofenac gel using different gelling agent. International Journal of Drug Development & Research, 3 (1), 156-164.
Sah SK, Badola A and Mukhopadhyay S. (2017). Development and evaluation of tioconazol loaded emulgel. International Journal of Applied Pharmaceutics, 9(5), 83-90.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
