Relationship between Escherichia coli and colon cancer

Abstract

Microbiota in the intestine provides major benefits to human health. The development of these microbiota depends on the individual's diet and lifestyle and is reflected in the impact of the microbiota on the body's energy and metabolism. In a normal healthy environment, Escherichia coli grows healthy and reflecting in the human body's metabolism. However, it has been known that there is linking the community of bacterial structure factors of the intestinal microbiota to colorectal cancer development and progression, E. coli can infect and cause changes in the gut that can finally lead to cellular transformation. Thus, chronic inflammation induced by E. coli during inflammatory bowel disease predisposes an individual to colorectal cancer. E. coli is a type species of the genus Escherichia. E. coli is a Gram-negative bacillus, facultative anaerobe, motile. E. coli producing many of toxin such as colibactin is a hybrid nonribosomal peptide-polyketide encoded by polyketide synthase (pks) can induce DNA double-strand breaks leading to chromosomal aberrations and increases the frequency of gene mutations and able to induce senescence-associated secretome to contribute to colon cancer development. Therefore, the study aims to investigate the bioactivity of E. coli on colon cell that has transformed to a cancer cell and to understand the E. coli as microbiota behavior in a certain environment the effect of this new environment on its activities.