Review on synthetic study of benzotriazole

Datta Avhad; Alpana Asnani; Shrikant Mohurle; Pratyush Kumar; Abhibnav Bais; Ruchita Tale

doi:10.30574/gscbps.2020.11.2.0137

Authors

Datta Avhad Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).
Alpana Asnani Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).
Shrikant Mohurle Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).
Pratyush Kumar Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).
Abhibnav Bais Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).
Ruchita Tale Department of Pharmaceutical Chemistry, Priyadarshini J. L. College of Pharmacy, Nagpur-440016, (Maharashtra), (India).

DOI:

https://doi.org/10.30574/gscbps.2020.11.2.0137

Keywords:

Benzotriazole, Antimicrobial, Anticancer, Antifungal, Fused heterocycles

Abstract

Benzotriazole is nitrogen containing heterocycle derivative containing three nitrogen atoms at 1st, 2nd, 3 rd positions. Lone pairs of each nitrogen atom are present in unshared form. The unshared lone pair of electrons enables five-membered ring to exhibit that can exist in tautomeric forms. Benzotriazole belongs to a fused heterocycles, which has a benzene ring fused with with a traizole ring. Benzotriazole and its derivatives have great significance in medicinal chemistry. The derivatives are used by several chemists for therapeutic conditions. The current paper concise several synthetic methods utilized for synthesizing derivativeswhich acts as antimicrobials, antibacterial, antifungal, antiviral, antitubercular, anticancer, anti-inflammatory, anticonvulsant, analgesic and antioxidant agents. The article will also help the researchers to understand the structure activity relationships and improvise the conceptsin their researches.

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