The oral film delivery- Application of nanotechnology and potential in medication adherence

Daniel Ekpa Effiong; Romanus Asuquo Umoh; Akwaowo Elijah Akpabio; Ndiana-Abasi Ime Sunday; Ini Uko Anamanyie

doi:10.30574/gscbps.2020.11.3.0154

Authors

Daniel Ekpa Effiong Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.
Romanus Asuquo Umoh Department of Pharmacognosy and Natural Medicine, University of Uyo, Nigeria.
Akwaowo Elijah Akpabio Department of Clinical and Bio-Pharmacy University of Uyo, Nigeria.
Ndiana-Abasi Ime Sunday National Institute of Pharmaceutical Research and Development, Abuja, Nigeria.
Ini Uko Anamanyie Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

DOI:

https://doi.org/10.30574/gscbps.2020.11.3.0154

Keywords:

Oral films, Nanobased oral films, Nanotechnology, Medication adherence, Chronic conditions

Abstract

The use of medicines is an irreplaceable necessity in healthcare delivery. Application of advancing technology, especially the oral film techniques in pharmaceutical production has resulted in medicine availability in a trendy, readily acceptable and usable form, oral films. Although many literature abound on oral film delivery systems, there is paucity of work on recent incorporation of nanotechnology concepts and the potentials of this delivery system in improving medication adherence. Thus this work focuses on bridging this obvious gap. It reviews published works on the oral film technology, profiling recent advances in the nanoparticles incorporated into films, and necessary considerations in such formulations. It also explores oral films as a delivery system for improved adherence. Online search for articles on oral films production, marketed nanoparticle-based oral films, and the extensiveness of medication non-adherence was carried out using websites of researchgate, google search, film manufacturer’s websites, google scholar and pubmed. Search terms used were ‘marketed oral films’, ‘available medicines as oral films’, ‘nanotechnology in oral film production’, ‘oral film techniques’, ‘oral films manufacture + disease condition’ and ‘medicine adherence’. Articles were sorted on the basis of currency and practicality of information. The market space of oral film is growing steadily. Present use of oral film technology in delivering antipsychotics, antihistamines and analgesics is well received. Many drugs are currently incorporated into films in nano-sized forms to improve dissolution, bioavailability and effectiveness as revealed by the search. More can be achieved if this technology is extended to cover other classes of drugs such as antihypertensives, antiulcers and agents indicated for other chronic conditions. Fully exploring the unique features of the conventional oral films dosage forms and those embedded with nanoparticulate drug forms, therein lies the potentials to contribute to significant improvement in medication adherence even in chronic conditions.

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