Rutin and Vitamin E alleviate oxidative stress and hepatic-renal injury induced by technical and formulated Lambda-cyhalothrin in adult rats
DOI:
https://doi.org/10.30574/gscbps.2020.12.1.0204Keywords:
Lambda-cyhalothrin, Rutin, Vitamin E, Oxidative stress biomarkers, RatsAbstract
Lambda-cyhalothrin (LCT) is a widely used pyrethroid to control insect pests in agriculture, public health and homes. The present study was designed to assess some of the toxicological effects in male rats following exposure to technical and formulated lambda-cyhalothrin (LCT T and LCT F.) and to evaluate the ameliorative effect of Vitamin E and Rutin administration. Nine groups of rats were designated for: control group; RT (50 mg kg-1 b.wt.); Vitamin E (100 mg kg-1 b.wt.); LCT T. (20 mg kg-1 b.wt); [LCT T. +Vitamin E]; [LCT T. +Rutin]; LCT F. (20 mg a.i. kg-1 b.wt); [(LCT F.) +Vitamin E] and [(LCT F.) +Rutin]. Results revealed that both of technical and formulated lambda-cyhalothrin treatments caused significant increase in LPO level and decrease in the activities of antioxidant enzymes: catalase, superoxide dismutase, glutathione-s-transferase Glutathione peroxidase, and glutathione reductase. Also, both forms of lambda-cyhalothrin caused significant increase in the activity of alanine and aspartate transaminases and alkaline phosphatase, lactate dehydrogenase and creatinine, uric acid levels, whereas albumin, total protein were decreased. Co-administration of Vit.E or Rutin achieved noticeable ameliorative effects. Thus, the overall results revealed the powerful ameliorating effect of Vit.E and Rutin in pyrethroids (e.g.LCT)-intoxicated rats.
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Giray B, Gurbay A and Hincal F. (2001). Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol. Toxicol Lett, 118, 139–146.
El-Demerdash FM, Yousef MI, Kedwany FS and Baghdadi HH. (2004). Role of a-tocopherol and b-carotene in ameliorating the fenvalerate induced changes in oxidative stress, hemato-biochemical parameters and semen quality of male rats. J. Environ. Sci. Health, B39, 443-459.
Prasanthi K, Muralidhara and Rajini PS. (2005). Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil. Food Chem. Toxicol, 43, 299–306.
Yousef M, Awad T and Mohamed E. (2006). Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E. Toxicology, 227, 240–247.
Nice D. (1997). Antioxidant based nutraceuticals. In: YalpaniM (Edn), New Technologies for Healthy Foods and Nutraceuticals. Science Publishers, Shrewsbury, 105-123.
Deschner EE, Ruperto J, Wong G and Newmark HL. (1991). Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis; 12, 1193–1196.
Janbaz KH, Saeed SA and Gilani AH. (2002). Protective effect of rutin on paracetamol and CCl4 induced hepatotoxicity in rodents. Fitoterapia, 73, 557–563.
Yin Z, Wang J, Gu X, Gu H and Wen y. (2012). Antioxidant and a-glucosidase inhibitory activity of red raspberry (Harry waters) fruits in vitro. Afr J Pharm Pharmacol, 6(45), 3118-3123.
Shalaby MA, HY El-Zorba, Gihan and Kamel M. (2004). Effect of alphatocopherol and simvastatin on male fertility in hypercholesterolemic rats. Pharmacol. Res, 50(2), 137-142.
Ramachandran V and Raja B. (2010). Protective effects of vitamin E and syringic acid against acetaminophen induced hepatic damage in albino rats. J. Basic Clin. Physiol. Pharmacol, 21(4), 369-385.
Iranloye BO and Oludare GO. (2011). Garlic and vitamin E provides antioxidant defense in tissues of female rats treated with nicotine. Nigerian J. Physiol. Sci, 26, 103-107.
NRC. (1996). Guide for the Care and Use of Laboratory Animals, National Research Council, Academic Press, Washington, DC, USA, 1996; p. 12.
Anadon A, M Mart´ınez, MA Mart´ınez, MJ D´ıaz and MR Mart´ınez-Larra˜naga. (2006). Toxicokinetics of lambda-cyhalothrin in rats. Toxicol. Letters, 165, 47–56.
Caria H, T Chaveca, A Laires and J Rueff. (1995). Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochore-containing (CREST staining) micronuclei in human lymphocytes. Mutat. Res, 343, 85–94.
Ohkawa H, Ohishi N and Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351–358.
Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82, 70–77.
Misra HP and Fridovich I. (1972). The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem, 247, 3170–3175.
Aebi H. (1984). Catalase in vitro, 3rd ed. Methods in Enzymology, Vol. 105. Philadelphia: Lippincott-Raven Publishers, 121–126.
Paglia and Valentine. (1967). J. Lab. Clin. Med., 70, 158–169.
Habig WH, Pabst MJ and Jakoby WB. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem, 249, 7130–7139.
Hafeman DG, Sunde RA and Hoekstra WG. (1974). Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr, 104, 580–587.
Principato GB, Asia MC, Talesa V, Rosi G and Giovannini E. (1985). Characterization of the soluble alkaline phosphatase from hepatopancreas of Squilla mantis L. Comp Biochem Physiol B, 985, 801–804.
Reitman S and Frankel S. (1957). A method of assaying liver enzymes in human serum. American Journal of Clinical Pathology, 28, 56 – 58.
Cabaud PC and Wroblewski F. (1958). Calorimetric measurement of lactate dehydrogenase activity of body fluids. J Clin Pathol, 30, 234–236.
Lowry OH, Rosebrough NJ, Farr AL and Randall RJ. (1951). Protein Measurement with the Folin phenol reagent. J Biol Chem, 193, 269–275.
Morgenstern S, Flor RV, Kaufman JH and Klein B. (1966). The automated determination of serum uric acid. Clin. Chem, 12, 748-766.
Mitchell RJ. (1973). Improved method for specific determination of creatinine in serum and urine. Clin. Chem, 19, 408 - 410.
Mansour SA and Gamet-Payrastre L. (2016). Ameliorative effect of vitamin E to mouse dams and their pups following exposure of mothers to chlorpyrifos during gestation and lactation periods.Toxicol. Ind. Health, 32, 1179-1196.
El-Shenawy NS, El-Salmy F, Al-Eisa RA and El-Ahmary B. (2010). Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver.Pest Biochem Physiol, 96, 101–107.
Kalender S et al. (2005). Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultra-structural changes. Toxicology, 211, 197–206.
Abbassy MA and ATH Mossa. (2012). Haemato-biochemical effects of formulated and technical cypermethrin and deltamethrin insecticides in male rats. J. Pharmacol. Toxicol, 7, 312-321.
Bal R, Naziro_glu M, T€urk G, Yilmaz €O, Kulo_glu T, Etem E and Baydas G. (2012). Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats. Cell Biochem Funct, 30, 492–499.
Ranjbar A, Solhi H, Mashayekhi F, Susanbdi J, Rezaie A and Abdollahi M. (2005). Oxidative stress in acute human poisoning with organophosphorus insecticides; a case control study. Environ Toxicol Pharmacol, 20, 88–91.
Bagchi D, Bagchi M, Hassoun EA and Stohs SJ. (1995). In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology, 104, 129-140.
Ali BJ, Hoda MN and Fatma M. El-Demerdash (2013). Selenium Modulates b-Cyfluthrin-Induced Liver Oxidative Toxicity in Rats. Environmental Toxicology Wiley Online Library (wileyonlinelibrary.com).
Eraslan G, Kanbur M, Silici S, Altinordulu S and Karaback M. (2008). Effects of cypermethrin on some biochemical changes in rats, the protective role of propolis. Exp Anim, 57, 453–460.
Eraslan G, Saygi S, Essiz D, Aksoy A, Gul H and Macit E. (2007). Evaluation of aspect of some oxidative stress parameters using vitamin E, proanthocyanidin and N-acetylcysteine against exposure to cyfluthrin in mice. Pest Biochem Physiol, 88, 43–49.
El-Demerdash FM. (2007). Lambda-cyhalothrin-induced changes in oxidative stress biomarkers in rabbit erythrocytes and alleviation effect of some antioxidants. Toxicol In Vitro, 21, 392–397.
El-Demerdash FM. (2011). Oxidative stress and hepatotoxicity induced by synthetic pyrethroids-organophosphate insecticides mixture in rat. J Environ Sci Health C, 29, 145–158.
Nasuti C, Cantalamessa F, Falcioni G and Gabbianelli R. (2003). Different effects of type I and type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats. Toxicology, 191, 233–244.
Fetoui H, E Garoui and N Zeghal. (2009). Lambda-cyhalothrin-induced biochemical and histopathological changes in the liver of rats: Ameliorative effect of ascorbic acid. Experimental and Toxicologic Pathology, 61, 189–196.
Oda SS and El-Maddawy Z. (2012). Protective effect of vitamin E and selenium combination on deltamethrin-induced reproductive toxicity in male rats. Experimental and Toxicologic Pathology, 64, 813-819.
Cerolini S, Zaniboni L, Maldjian A and Gliozzi T. (2006). Effect of docosa hexaenoic acid and alpha tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. Theriogenology, 66, 877–886.
Yousef M. (2010). Vitamin E modulates reproductive toxicity of pyrethroid lambda-cyhalothrin in male rabbits. Food and Chemical Toxicology, 48, 1152-1159.
Manivannan C, Sundaram KM, Renganathan R and Sundararaman M. (2012). Investigations on photoinduced interaction of 9-aminoacridine with certain catechols and rutin. J Fluoresc, 22, 1113–1125.
Becker EM, Ntouma G and Skibsted LH. (2007). Synergism between and antagonism between quercetin and other chain-breaking antioxidants in lipid systems of increasing structural organization. Food Chem, 103, 1288–1296.
Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam F, Siddiqui MS, Safhi MM and Islam F.(2012). Rutin prevents cognitive impairments by ameliorating oxidative stress and neuro inflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience, 17, 340–352.
Yang YC, Lin HY, Su KY, Chen CH, Yu YL, Lin CC, Yu SL, 40- Yan HY, Su KJ and Chen YL. (2012).Rutin, a flavonoid that is a main component of Saussurea involucrata, attenuates the senescence effect in D-Galactose aging mouse model. Evid Based Complement Alternat Med, 980276.
Nakayama T, Yamada M, Osawa T and Kawakishi S. (1993). Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem Pharmacol, 45, 265–267.
Teimouri F, Amirkabirian N, Esmaily H, Mohammadirad A, Ali ahmadi A and Abdollahi M. (2006). Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxification mechanism in counteracting diazinon induced oxidative stress. Hum.Exp.Toxicol, 25, 697–703.
Zak R, Martin AF, Reddy MK and Rabinowitz M. (1976). Control of protein balance in hypertrophied cardiac muscle. Circ Res; 38 (5 supp1), 1145.
Mansour SA, Abbassy MA and Shaldam HA. (2017). Zinc ameliorate oxidative stress and hormonal disturbance induced by methomyl, abamectin and their mixture in male rats. Toxics, 5(37).
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