Development and formulation of Aloe vera emulgel

Manna Mahuli; Rudra Anandamoy

doi:10.30574/gscbps.2020.12.2.0262

Authors

Manna Mahuli Associate Professor, Bengal School of Technology, Sugandha, Delhi Road, Hooghly-712102, West Bengal, India.
Rudra Anandamoy Associate Professor, Bengal School of Technology, Sugandha, Delhi Road, Hooghly-712102, West Bengal, India.

DOI:

https://doi.org/10.30574/gscbps.2020.12.2.0262

Keywords:

Aloe vera gel, Carbomer 940, Emulgel, Fourier transform infrared (FTIR) spectroscopy, Dynamic light scattering (DLS), Dermal preparation

Abstract

Aloe vera is most popular in treatment of dermatological disorder in case of burn, tan and wound healing. The study was designed for crude Aloe vera extract, development of oil in water (o/w) emulsion, preparation of gel base using Aloe vera extract and formulation of the emulgel for topical application. The formulation was prepared by using carbomer 940 as polymer and isopropyl alcohol as penetration enhancer. The p^H and viscosity of the Aloe vera emulgel were noticed to be 6.8 and 750 centipoise (cps) respectively. The interaction study between phytochemicals and the excipients was carried out using Fourier transform infrared (FTIR) spectroscopy. UV spectrometric analysis of plant extract was carried out. Dynamic light scattering (DLS) was performed to determine the particle size distribution of oil globules in emulsion. Mean particle size (oil globules) was observed to be 481 nm. Zeta potential and polydispersity index (PDI) was recorded to be -13.2 mV and 0.6 respectively

Metrics

Metrics Loading ...

References

Mikari BV and Mahadik KR. (2010). Formulation and evaluation of topical liposomal gel for fluconazole. Indian J Pharm Science, 44(4), 324-325.

Baibhav J. (2012). Development and characterization of clarithromycin emulgel for topical delivery. International Journal of Drug Development and Research, 4(3), 310-323.

Liu P and Chen D. (2013). Chemical constituents, biological activity and agricultural cultivation of Aloe vera, Asian Journal of Chemistry, (12), 6477-6485.

Cole L and Heard C. (2007). Skin permeation enhancement potential of Aloe vera and a proposed mechanism of action based upon size exclusion and pull effect. Int J Pharm, 333, 10–16.

Forever Good Health, The Aloe Way, health care magazine, Forever Living Products; India, Pvt. Ltd. (2009). 3-22.

Sierra-Garcia GD and Castro-Rios R. (2014). Acemannan, an extracted polysaccharide from Aloe vera: A Literature Riview. Natural Product Communications, 9(8), 1217-1221.

Das T, Manna M and Rudra A. (2020). Formulation and characterization of papaya leaf gel. GSC Biological and Pharmaceutical Sciences, (3), 89-94.

Rudra A, Deepa RM, Ghosh MK, Ghosh S and Mukherjee B. (2010). Doxorubicin-loadeded phosphatidyl ethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. International Journal of Nanomedicine, 5, 811-823.

Sumathi A andSuriyaprakash TNK. (2016). Formulation and characterization of aloe emulgel using rice hulls as an excipient. Internation Journal of Research in Pharmacology & Pharmaco therapeutics, 1, 24-31.

Herbert AL, Martin MR andGilbert SB. (1988). Pharmaceutical emulsions, pharmaceutical dosage forms: Disperse System.Vol.1, Marcel Dekkar, New York and Basel.

Megeressa M, Bisrat D and Mazumder A. (2015). Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach. BMC Complementary and Alternative Medicine, 15:270

Pecora R. (2000). Dynamic light scattering measurement of nanometer particles in liquids. Journal on Nanoparticle Research, 2(2), 123-131.