Role of exercise and physical activity in prevention and management of chronic diseases

Bello Samuel; Adeniji Adedamola; Akeredolu Oladayo; Idowu Temitope

doi:10.30574/gscbps.2020.12.3.0277

Authors

Bello Samuel Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Adeniji Adedamola Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Akeredolu Oladayo Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Idowu Temitope Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.

DOI:

https://doi.org/10.30574/gscbps.2020.12.3.0277

Keywords:

Chronic disease, Physical activity, Exercise, Prevention, Management, Treatment

Abstract

The burden of chronic disease and the cost of treatment and management has skyrocketed. According to the World Health Organization (WHO), an estimated 17.9 million people died from cardiovascular diseases (CVDs) in 2016 making it the leading cause of death. Cancer is the second leading cause of death globally and was responsible for an estimated 9.6 million deaths in 2018, there are other chronic diseases which include obesity, diabetes, chronic obstructive pulmonary diseases (COPD), dementia and Alzheimer’s disease. Most chronic diseases can be caused and aggravated by physical inactivity amongst other factors. However, physical activity and exercise when properly implemented demonstrate tremendous effect in the prevention and management of several chronic diseases and health related conditions. This review focuses on the role of exercise in prevention and management of chronic diseases and the biochemical mechanism underlying it.

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References

Anderson E, Durstine JL. Physical Activity, Exercise, and Chronic Diseases: A Brief Review, Sports Medicine and Health Science.

Booth FW, Laye MJ, Lees SJ, Rector RS, Thyfault JP. Reduced physical activity and risk of chronic disease: the biology behind the consequences. Eur J Appl Physiol. 2008; 102: 381–390.

Booth FW, Lees SJ. Fundamental questions about genes, inactivity and chronic diseases. Physiol Genomics. 2007; 28: 146–157.

Olsen RH, Krogh-Madsen R, Thomsen C, Booth FW, Pedersen BK. Metabolic responses to reduced daily steps in healthy nonexercising men. JAMA. 2008; 19: 1261–1263.

Katzmarzyk PT, Lear SA. Physical activity for obese individuals: a systematic review of effects on chronic disease risk factors. Obes Rev. 2012; 13(2): 95-105.

Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence, Acta Diabetologica. 2010; 47(1): 15–22.

S Zanuso, S Balducci, A Jimenez. Physical activity, a key factor to quality of life in type 2 diabetic patients, Diabetes/Metabolism Research and Reviews. 2009; 25(1): S24–S28.

National Institutes of Health, National Heart, Lung, and Blood Institute. Your Guide to Physical Activity and Your Heart". U.S. Department of Health and Human Services. 2006.

Saeid G, Badran M, Laher I. Antioxidant and Anti-Inflammatory Effects of Exercise in Diabetic Patients. Experimental Diabetes Research. 2012; 941868.

Tung Y-T, Hsu Y-J, Liao C-C, Ho S-T, Huang C-C, Huang W-C. Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches. Front. Physiol. 2019; 10: 1201.

Blair SN, Kohl HW, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA. 1989; 262: 2395–2401.

McGinnis JM, Foege WH. Actual causes of death in the United States. JAMA. 1993; 270: 2207–2212.

Schwarzer M, Britton SL, Koch LG, Wisloff U, Doenst T. Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity. Basic. Res. Cardiol. 2010; 105: 357–364.

Pekkala S, Lensu S, Nokia M, Vanhatalo S, Koch LG, Britton SL, et al. Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings. Physiol. Genom. 2017; 49: 733–746.

Koch LG, Britton SL. Theoretical and biological evaluation of the link between low exercise capacity and disease risk. Cold Spring Harb. Perspect. Med. 2018; 8: a029868.

Joyner MJ, Coyle EF. Endurance exercise performance: the physiology of champions. J. Physiol. 2008; 586, 35–44.

Munoz A, Riber C, Trigo P, Castejon-Riber C, Castejon FM. Dehydration, electrolyte imbalances and renin-angiotensinaldosteronevasopressin axis in successful and unsuccessful endurance horses. Equine. Vet. J. 2010; 42: 83–90.

Russell AP, Lamon S, Boon H, Wada S, Güller I, Brown EL, et al. (2013). Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J. Physiol. 2013; 591: 4637–4653.

Snow DH, Baxter P, Rose RJ. Muscle fibre composition and glycogen depletion in horses competing in anendurance ride. Vet. Rec. 1981; 108: 374–378.

Turner JE, Lira VA, Brum PC. New insights into the benefits of physical activity and exercise for aging and chronic disease. Oxidative Med Cell Longev. 2017.

Aoike DT, Baria F, Kamimura MA, Ammirati A, Cuppari L. Home-based versus center-based aerobic exercise on cardiopulmonary performance, physical function, quality of life and quality of sleep of overweight patients with chronic kidney disease. Clin Exp Nephrol. 2018; 22(1): 88–96.

Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG. Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms. Physiol Rev. 2017; 97: 1350–1400.

Hamman RF, Wing RR, Edelstein SL, et al. Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care. 2006; 29(9): 2102-2107.

Ades P, Balady G, Berra K. Transforming Exercise-based Cardiac Rehabilitation Programs into Secondary Prevention Centers: A National Imperative. J Cardiopulm Rehabil Prev. 2001; 21(5): 264-271.

Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006; 174(6): 801-809.

Fogelholm M. Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev. 2010; 11(3): 204-220.

Brownell KD. The LEARN program for weight management 2000. Dallas: American Health Publishing Company. 2000.

Moore GE. The role of exercise prescription in chronic disease/ Br J Sports Med. 2004; 38: 5-7.

Laskowski E. The effect of exercise in the treatment of obesity Mayo Clinic, Physical Medicine and Rehabilitation, Rochester, MN, USA. 13 July 2018.

Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012; 2(2): 1143-1211.

Friedenreich CM, Woolcott CG, McTiernan A, et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int J Obes. 2010; 35: 422–432.

Aune D, Norat T, Leitzmann M, Tonstad S, Vatten LJ. Physical activity and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis. Eur J Epidemiol. 2015; 30: 530–542.

Hu G, Lindstrom J, Valle TT, et al. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med. 2004; 164: 892.

George A. Kelley, Kristi S. Kelley. Effects of Exercise in the Treatment of Overweight and Obese Children and Adolescents: A Systematic Review of Meta-Analyses Hindawi Publishing Corporation Journal of Obesity. 2013, Article ID 783103, 10.

World Health Organization. Assessing national capacity for the prevention and control of noncommunicable diseases. Geneva: WHO. 2012.

World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: AICR. 2007.

World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity and colorectal cancer. 2017.

Keum N, Bao Y, Smith-Warner SA, Orav J, Wu K, Fuchs CS, Giovannucci EL. Association of physical activity by type and intensity with digestive system cancer risk. JAMA Oncol. 2016; 2: 1146–53.

World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of breast cancer. 2010.

Schmid D, Behrens G, Keimling M, Jochem C, Ricci C, Leitzmann M. A systematic review and meta-analysis of physical activity and endometrial cancer risk. Eur J Epidemiol. 2015; 30: 398–410.

Moore SC, Lee IM, Weiderpass E, Campbell PT, Sampson JN, Kitahara CM, Keadle SK, Arem H, Berrington de Gonzalez A, Hartge P, Adami H-O, Blair CK, Borch KB, Boyd E, Check DP, Fournier A, Freedman ND, Gunter M, Johannson M, Khaw K-T, Linet MS, Orsini N, Park Y, Riboli E, Robien K, Schairer C, Sesso H, Spriggs M, Van Dusen R, Wolk A, Matthews CE, Patel AV. Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Intern Med. 2016; 176: 816–25.

I-Min Lee, Paffenbarger RS Jr. The Role of Physical Activity in the Prevention of Coronary Artery Disease. In: Paul D Thompson, editor. Exercise and Sports Cardiology. 1st ed. New York: Mc Graw Hill. 2001; 384-400.

Lee DC, Pate RR, Lavie CJ, Sui X, Church TS, Blair SN. Leisure-time running reduces all-cause and cardiovascular mortality risk. J Am Coll Cardiol. 2014; 64: 473–480.

Smith SC Jr, Collins A, Ferrari R, et al. Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke). Circulation. 2012; 126: 2770–2774.

Carson KV, Chandratilleke MG, Picot J, Brinn MP, Esterman AJ, Smith BJ. Physical training for asthma. Cochrane Database Syst Rev. 2013; 9: CD001116.

Nguyen HQ, Chu L, Amy Liu IL, et al. Associations between physical activity and 30-day readmission risk in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014; 11: 695 705.

Renolleau-Courtois D, Lamouroux-Delay A, Delpierre S, et al. Home-based respiratory rehabilitation in adult patients with moderate or severe persistent asthma. J Asthma. 2014; 51: 552-558.

Corbridge SJ and Nyenhuis SM. Promoting Physical Activity and Exercise in Patients with Asthma and Chronic Obstructive Pulmonary Disease. The journal for nurse practitioners. January 2017; 13(1): 41-46.

Burr JF, Davidson W, Shephard RJ, Eves N. Assessing risks for physical activity clearance and prescription. 2012; 58: 761-764.

Vaes AW, Garcia-Aymerich J, Marott JL, et al. Changes in physical activity and all-cause mortality in COPD. Eur Respir J. 2014; 44: 1199-1209.

Ferreira-Vieira TH, Bastos CP, Pereira GS, Moreira FA, Massensini AR. A role for the endocannabinoid system in exerciseinduced spatial memory enhancement in mice. Hippocampus. 2014; 24: 80–88.

Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, et al. A runner’s high depends on cannabinoid receptors in mice. Proc. Natl. Acad. Sci. U.S.A. 2015; 112: 13105–13108.

Mammen G, Faulkner G. (2013). Physical activity and the prevention of depression: a systematic review of prospective studies. Am. J. Prev. Med. 2013; 45: 650–657.

De Moor MH, Beem AL, Stubbe JH, Boomsma DI, De Geus EJC. (2006). Regular exercise, anxiety, depression and personality: a populationbased study. Prev. Med. 2006; 42: 272–279.

Hötting K, Schickert N, Kaiser J, Röder B, Schmidt-Kassow M. The effects of acute physical exercise on memory, peripheral bdnf, and cortisol in young adults. Neural Plast. 2016; 1–12.

Mandolesi L, Gelfo F, Serra L, Montuori S, Polverino A, Curcio G, et al. Environmental factors promoting neural plasticity: insights from animal and human studies. Neural Plast. 2017; 1–10.

Fernandes J, Arida RM, Gomez-Pinilla F. Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neurosci. Biobehav. Rev. 2017; 80: 444–456.

Chieffi S, Messina G, Villano I, Messina A, Valenzano A, Moscatelli F, et al. Neuroprotective effects of physical activity: evidence from human and animal studies. Front. Neurol. 2017; 8: 188.

Niemann C, Godde B, Staudinger UM, Voelcker-Rehage C. Exercise-induced changes in basal ganglia volume and cognition in older adults. Neuroscience. 2014; 281: 146–163.

Hollamby A, Davelaar EJ, Cadar D. Increased physical fitness is associated with higher executive functioning in people with dementia. Front. Public Heal. 2017; 5: 346.

Pedrinolla A, Schena F, Venturelli M. Resilience to Alzheimer’s disease: the role of physical activity. Curr. Alzheimer Res. 2017; 14: 545–552.

Gureev AP, Shaforostova EA, Popov VN. Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways. Front Genet. 2019; 10: 435.

Liang H, Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ. 2006; 30(4): 145-151.

Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006; 27: 728–735.

Bonen A, Dohm GL, van Loon LJ. Lipid metabolism, exercise and insulin action. Essays Biochem. 2006; 42: 47–59.

Lira VA, Benton CR, Yan Z, Bonen A. PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab. 2010; 299(2): E145-E161.

Done AJ, Traustadóttir T. Nrf2 mediates redox adaptations to exercise. Redox Biol. 2016; 10: 191-199.

Rothman SM, Griffioen KJ, Wan R, Mattson MP. Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health. Ann. N.Y. Acad. Sci. 2012; 1264: 49–63.

Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30: 464–472.

Ivy AS, Rodriguez FG, Garcia C, Chen MJ, Russo-Neustadt AA. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol. Biochem. Behav. 2003; 75, 81–88.

Voss MW, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum. Brain Mapp. 2013; 34, 2972–2985.