Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Bazoma Bayili; Ollo Da; Sylvain Ilboudo; Richard Ouedraogo; Véronique Panne Coulibaly; Jean Fidèle Bationo; Jean Bosco Ouedraogo; Georges Anicet Ouedraogo

doi:10.30574/gscbps.2020.13.1.0323

Authors

Bazoma Bayili Institut de Recherche en Sciences de la Santé (IRSS), Direction Régional de l’Ouest (DRO), Bobo-Dioulasso, Burkina Faso. 2 Université Nazi Boni (UNB), Bobo Dioulasso, Burkina Faso.
Ollo Da Département de Laboratoire, service de biochimie, Centre Hospitalier Universitaire Souro SANOU.
Sylvain Ilboudo Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso.
Richard Ouedraogo Institut de l'Environnement et de Recherches Agricoles (INERA), Direction Régionale de Recherche Environnementale et Agricole de l’Ouest, Bobo Dioulasso (INERA/DRREA-O), Burkina Faso.
Véronique Panne Coulibaly Université Nazi Boni (UNB), Bobo Dioulasso, Burkina Faso.
Jean Fidèle Bationo Centre Muraz, Bobo Dioulasso, Burkina Faso.
Jean Bosco Ouedraogo Institut de Recherche en Sciences de la Santé (IRSS), Direction Régional de l’Ouest (DRO), Bobo-Dioulasso, Burkina Faso.
Georges Anicet Ouedraogo Université Nazi Boni (UNB), Bobo Dioulasso, Burkina Faso.

DOI:

https://doi.org/10.30574/gscbps.2020.13.1.0323

Keywords:

Pesticides, Farmers, Biochemical parameters

Abstract

Repeated exposure to pesticides can cause a variety of human health problems, particularly among farmers. This work consisted in studying biochemical parameters and their evolution in cotton farmers exposed to pesticides.

A longitudinal study was conducted during and after the 2018/2019 cotton season on a cohort of cotton farmers around the Bala hippopotamus pond in the department of Satiri. Biochemical parameters were measured during and after the crop year on the Architect ci 4100.

The majority of the farmers had high uric acid (UA) and low blood sugar (Gluc) concentrations. A few had concentrations of Cholinesterase (ChE) (6.19%); Direct Bilirubin (BilD) (23.01%); Gamma Glutamyl Transferase (GGT) (8.85%); Alkaline Phosphatase (ALkP) (4.42%); Cholesterol (Chol) (4.42%); triglycerides (Trig) (4.42%); aspartate aminotransferase (AST) (4.42%) higher than normal and lower than normal albumin (Alb) (13.27%) and total protein (TP) (13.27%) concentrations. Analysis of the evolution of biochemical parameters showed that none of the producers had higher than normal ChE and TP concentrations. After the campaign, the number of producers with lower than normal values increased for AST, AlkP, Alb and Urea while those with higher than normal values increased for GGT, UA, Gluc, Chol, Trig and BilD. Also, a significant decrease in AST, ALT and creatinine (CreaC) concentrations and a significant increase in GGT and BilD concentrations were observed.

The existence of some disturbances of biochemical parameters in farmers should encourage to test the hypothesis of a link between pesticide exposure and the appearance of biochemical disorders in clinical trials.

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References

Shokrzadeh M, Saravi SSS. Pesticides in agricultural products: analysis, reduction, and prevention. department of toxicology-pharmacology, faculty of pharmacy, Mazandaran University of Medical Sciences, (2011).

Calvet R, Barriuso E, Bedos C, Benoit P, Charnay M-P, Coquet Y. Les Pesticides dans le sol: conséquences agronomiques et environnementales. 2005; ISBN 2-85557-119-7.

Glynn P. A mechanism for organophosphate-induced delayed neuropathy. Toxicology Letters. 2006; 162(1): 94–97.

Feng S, Kong Z, Wang X, Peng P, Zeng EY. Assessing the genotoxicity of imidacloprid and RH-5849 in human peripheral blood lymphocytes in vitro with comet assay and cytogenetic tests. Ecotoxicology and Environmental Safety. 2005; 61(2): 239–246.

Ning B, Graham N, Zhang YP, Nakoneching M, El Din MG. Degradation of endocrine disrupting chemical by ozone/AOPS. Ozone –Sciences and Engineering. 2007; 29 (3): 153-176.

Anger JP, Kintz P. Difficultés analytiques de la caractérisation des pesticides dans le sang Ann Toxicol Anal. 2009; 21(3): 131-141.

Toe AM, Ouedraogo M, Ouedraogo R, Ilboudo S, Guissou PI. Pilot study on agricultural pesticide poisoning in Burkina Faso. Interdiscip Toxicol. 2013; 6(4): 185-191.

Lehmann ERG, Nfon-Dibie J-J, Konate Y, De Alencastro LF. Pesticides use in gardening areas in Burkina Faso and evaluation of the resulting risk for the operator using the new AOEM proposed by EFSA guidelines. 2016.

Ouedraogo R, Toe AM, Ilboudo S, Guissou PI. Risk of workers exposure to pesticides during mixing/loading and supervision of the application in sugarcane cultivation in Burkina Faso. International Journal of Environmental Science and Toxicology Research. 2014; 2(7): 143-151.

Toe AM, Ilboudo S, Ouedraogo M, Guissou PI. Biological alterations and self-reported symptoms among insecticides-exposed workers in Burkina Faso. Interdiscip. Toxicol. 2012; 5(1): 42–46.

Anwar WA. Biomarkers of human exposure to pesticides. Environ Health Prest. 1997; 105(4): 801–806.

Benford DJ, Hanley AB, Bottrill K, Oehlschlager S, Balls M, Branca F, Castegnaro JJ, Descotes J, Hemminiki K, Lindsay D, Schilter B. Biomarkers as Predictive Tools in Toxicity Testing. ATLA. 2000; 28: 119-131.

Kapka-Skrzypczak L, Cyranka M, Skrzypczak M, Kruszewski M. Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. Ann Agric Environ Med. 201; 18(2): 294-303.

Banaee M, Akhlaghi M, Soltanian S, Gholamhosseini A, Heidarieh H, Fereidouni MS. Acute exposure to chlorpyrifos and glyphosate induces changes in hemolymph biochemical parameters in the crayfish, Astacus leptodactylus (Eschscholtz, 1823). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2019; 222: 145–155.

Bernieri T, Rodrigues D, Randon Barbosa I, Perassolo MS, Grolli Ardenghi P, Basso Da Silva L. Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers. Drug and Chemical Toxicology. 2019; 1–7.

Wafa T., Nadia K., Amel N, Ikbal C, Insaf T, Asma K, Abdel M, Mohamed HH. Oxidative stress, hematological and biochemical alterations in farmers exposed to pesticides, Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 2013; 48:12, 1058-1069.

Silins I, Högberg J. Combined Toxic Exposures and Human Health: Biomarkers of Exposure and Effect. International Journal of Environmental Research and Public Health. 2011; 8(3): 629–647.

Al-Sarar AS, Abo Bakr Y, Al-Erimah GS, Hussein HI, Bayoumi AE. Hematological and Biochemical Alterations in Occupationally Pesticides-Exposed Workers of Riyadh Municipality, Kingdom of Saudi Arabia. Research Journal of Environmental Toxicology. 2009; 3: 179-185.

Patil JA, Patil AJ, Sonttake, AV, Govindwar SP. Occupational pesticides exposure of sprayers of grape gardens in Western Maharashtra (India): effects on liver and kidney function. Journal of Basic and Clinical Physiology and Pharmacology. 2009; 20(4): 335-355.

Attia AM. Risk assessment of occupational exposure to pesticides. I. Linkov and A. Bakr Ramadan (eds.), Comparative Risk Assessment and Environmental Decision Making. 2004; 349–362.

Mohammadi K, Ichlihan M, Khallassi M, Safi A, Mohammadi H, Douira A, Maaroufi A, Aamouche A. Etude de verification technique d’un paramètre biochimique (créatinine sérique) sur l’automate Abbott selon la norme ISO 15189 v 2012. European Journal of Scientific Research. 2019; 155: 58 -69.

Rotterdam Convention, Use of agricultural pesticides in three regions of Burkina Faso and evaluation of their impact on health and the environnement: the case of the Boucle du Mouhoun, Cascades and Hauts-Bassins regions. Final report. 2016; 100.

Humbert A, Stucker F. Acid uric: key player in a recently recognized devastating nephropathy and in the development of chronic kidney disease. Rev Med Suisse. 2018; 14(595): 414-417.

Gaikwad AS, Karunamoorthy P, Kondhalkar SJ, Ambikapathy M, Beerappa R. Assessment of hematological, biochemical effects and genotoxicity among pesticide sprayers in grape garden. Journal of Occupational Medicine and Toxicology. 2015; 10(1).

Arrebola JP, Ramos JJ, Bartolome M, Esteban M, Huetos O, Cañas AI, Castaño A. Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study. Environment International. 2019; 123: 512–521.

Jyothi B, Narayan G. Pesticide induced alterations of non-protein nitrogenous constituents in the serum of a fresh water cat fish, Clarias batrachus (Linn.) Indian J Exp Biol. 2000; 38(10): 10-58-61.

Lotti M, Moretto A. Organophosphate-induced delayed polyneuropathy. Toxicological Reviews. 2005; 24: 37-49.

Starling AP, Umbach DM, Kamel F, Long S, Sandler DP et al. Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study. Occupational and Environmental Medicine. 2014; 71: 629-635.26.

Huang X, Zhang C, Hu R, Li Y, Yin Y et al. Association between occupational exposures to pesticides with heterogeneous chemical structures and farmer health in China. Scientific Reports. 2016; 6: 25190.

Gupta HPK. Pandey R, Anjum S. Occupational Exposure to Pesticide: A Risk of Diabetic Neuropathy. J Toxicol Anal. 2018; 1: 1: 4.

Harabawy ASA, Ibrahim ATA. Sublethal toxicity of carbofuran pesticide on the African catfish Clarias gariepinus (Burchell, 1822): Hematological, biochemical and cytogenetic response. Ecotoxicology and Environmental Safety. 2014; 103: 61–67.

Zidan NE-HA. Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains. Acta Biologica Hungarica. 2015; 66(2): 133–148.

Lasram MM, Annabi AB, Elj NE, Selmi S, Kamoun A, El-Fazaa S, Gharbi N. Metabolic disorders of acute exposure to Malathion in adult Wistar rats. Journal of Hazardous Materials. 2009; 163(2-3): 1052–1055.

Manfo FPT, Mboe SA, Nantia EA, Ngoula F, Telefo PB, Moundipa PF, Cho-Ngwa F. Evaluation of the Effects of Agro Pesticides Use on Liver and Kidney Function in Farmers from Buea, Cameroon. Journal of Toxicology. 2020; 1–10.