UV spectrophotometric method for estimation of zileuton in pharmaceutical formulation

Romana Mahivish; Manjunath SY; Hemant Kumar

doi:10.30574/gscbps.2020.13.1.0338

Authors

Romana Mahivish Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences, Siddipet-502 277 (TS).
Manjunath SY Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences, Siddipet-502 277 (TS).
Hemant Kumar Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences, Siddipet-502 277 (TS).

DOI:

https://doi.org/10.30574/gscbps.2020.13.1.0338

Keywords:

Zileuton, 0.1 N NaOH, UV-spectrophotometric method, ICH guidelines

Abstract

A simple, rapid, sensitive and accurate UV-spectrophotometric method has been developed for the estimation of zileuton in pharmaceutical formulation. The method was developed by using 0.1 N Sodium hydroxide as a solvent and absorbance was measured at 230 nm. The drug exhibited the linearity in the concentration range of 1-6 μg/ml with correlation coefficient of 0.9993. The % recovery of the drug was found to be 98.62 % - 100.5 %. The method was validated as per ICH guidelines. The proposed methods are economical and sensitive for the estimation of zileuton in bulk and tablet dosage form.

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