Effect of some Nigerian traditional alcoholic beverages on the estrous cycle and histological assessment of the ovaries and uterus of albino rats

Olusayo Moritiwon; Timothy Olugbenga Ogundeko; James Bitrus; David Oyebode; Olufunmilayo Ibiyemi Abobarin

doi:10.30574/gscbps.2021.14.1.0001

Authors

Olusayo Moritiwon Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Science, University of Jos Nigeria.
Timothy Olugbenga Ogundeko Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Bingham University, Jos Campus Nigeria.
James Bitrus Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Bingham University, Jos Campus Nigeria.
David Oyebode Department of Hematology, Federal School of Medical Laboratory Science, Jos University Teaching Hospital, Nigeria.
Olufunmilayo Ibiyemi Abobarin Department of Morbid Anatomy Histopathology and Morbid Anatomy, College of Medicine and Health Sciences, Bingham University, Jos Campus Nigeria

DOI:

https://doi.org/10.30574/gscbps.2021.14.1.0001

Keywords:

Pito, Burukutu, Ogogoro, Goskolo, Estrous cycle, Reprotoxicity

Abstract

Alcohol related health challenges have lingered over the years. Such associated with locally brewed alcoholic beverages have received little attention. The urgency to explore this becomes imperative. This study aimed at evaluating the effect of regular consumption of local alcoholic beverages on the estrous cycle and histological image of the ovaries and uterus thus fertility of female albino rats. Thirty screened female albino rats weighing 180-220g were divided into five groups and daily administered each with 10ml/kg of pito, burukutu, ogogoro, goskolo and 0.5ml/kg normal saline respectively for 21 days. Effect of the beverages on the estrous cycle as well as histopathological evaluation was carried out on the isolated ovaries and uterus. Results showed significant increase proestrous phase of the estrous cycle with ingestion of pito, burukutu, ogogorogo and goskolo. Also the histology of the ovary was basically without obvious pathological changes with pito, while there was alteration of histological parameters by burukutu, marked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle, ogogoro marked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle and goskolo marked with formation of multiple follicular cyst resulting in complete collapse of the ovarian section. The effect of traditional alcoholic beverages revealed the classical effects of alcoholic drinks by way of significant alteration in the estrous cycle of albino rats with marked alteration of the histological architecture of ovarian tissues. Pito, burukutu, ogogoro, and goskolo have a reprotoxic effect on the ovaries and uterus thus a deleterious effect on fertility of female albino rats.

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