A review on how exactly covid-19 vaccination works

Sheema Fatima Khan

doi:10.30574/gscbps.2021.14.1.0009

Authors

Sheema Fatima Khan Shadan Institute of Medical Sciences, Teaching Hospital and Research Center, Hyderabad-86, Telangana, India.

DOI:

https://doi.org/10.30574/gscbps.2021.14.1.0009

Keywords:

Coronavirus, Vaccination, Mutation, Heard immunity, mRNA, Adenovirus, Vectors, Efficacy, COVAX

Abstract

The Coronavirus pandemic has taken the world by storm, covering the entire year of 2020. In order to put an end to the pandemic many organizations around the world are racing to find a safe and effective vaccine. Today, newer technology of nucleic acid vaccine has been use to create a novel vaccine for novel coronavirus. Many countries like the United States of America, United Kingdom and even Russia and China have successfully developed approved vaccines. But there remains a doubt of uncertainty among people regarding how fast this vaccine was created when compared to others which have taken years. This review aims to highlight and summarize the ongoing process and development in making Covid vaccines.

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References

Enjuanes L, Almazán F, Sola I, Zuñiga S. Biochemical Aspects of Coronavirus Replication and Virus-Host Interaction. Annual Review of Microbiology. 2006; 60(1): 211-230.

Perlman S, Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nature Reviews Microbiology. 2009; 7(6): 439-450.

Myint S. Human Coronavirus Infections. The Coronaviridae. 1995; 389-401.

Wise J. Covid-19: New coronavirus variant is identified in UK. BMJ. 2020.

Cuevas JM, Geller R, Garijo R, López-Aldeguer J, Sanjuán R. Extremely high mutation rate of HIV-1 in vivo. PLoS Biol. 16 Sep 2015; 13(9).

Lewis-Rogers N, Seger J, Adler F. Human Rhinovirus Diversity and Evolution: How Strange the Change from Major to Minor. Journal of Virology. 2017; 91(7).

Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P, Masciovecchio C, Angeletti S, Ciccozzi M, Gallo RC, Zella D. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. Journal of Translational Medicine. Dec 2020; 18: 1-9.

Xia S, Duan K, Zhang Y, Zhao D, Zhang H, Xie Z et al. Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes. JAMA. 2020; 324(10): 951.

Cohen J. Shots of hope [Internet]. Science. 2021.

Burki T. The Russian vaccine for COVID-19. The Lancet Respiratory Medicine. 2020; 8(11).

COVAXIN - India's First Indigenous Covid-19 Vaccine | Bharat Biotech [Internet]. Bharatbiotech.com. 2021.

About Vaccine | Official website vaccine against COVID-19 Sputnik V. [Internet]. Sputnikvaccine.com. 2021.

Cohen J. Russia’s approval of a COVID-19 vaccine is less than meets the press release [Internet]. Science | AAAS. 2021.

Mahase E. Covid-19: Russia approves vaccine without large scale testing or published results. BMJ. 2020; 370: m3205.

Salem M, Xiong Y. China's Sinopharm vaccine has 86% efficacy against Covid-19, says UAE [Internet]. CNN. 2021.

Different efficacy data for Sinopharm COVID-19 vaccine 'real and valid': Media [Internet]. CNA. 2021.

Sempowski G, Saunders K, Acharya P, Wiehe K, Haynes B. Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19. Cell. 2020; 181(7): 1458-1463.

COVID-19 vaccine tracker [Internet]. Raps.org. 2021.

How Do Viruses Mutate and What it Means for a Vaccine? | Breakthroughs [Internet]. Breakthroughs.com. 2021.

Polack F, Thomas S, Kitchin N, Absalon J, Gurtman A, Lockhart S et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. New England Journal of Medicine. 2020; 383(27): 2603-2615.

Baden L, El Sahly H, Essink B, Kotloff K, Frey S, Novak R et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine. 2020.

Saunders WB. Dorland’s Illustrated Medical Dictionary. 28th Edn. Philadelphia: 1994; 812.

John T, Samuel R. Herd immunity and herd effect: new insights and definitions. European Journal of Epidemiology. 2000; 16(7): 601-606.

COVAX explained [Internet]. Gavi.org. 2021.

Mahase E. Covid-19: Moderna vaccine is nearly 95% effective, trial involving high risk and elderly people shows. BMJ. 2020; 371: m4471.

Subbaraman N. Who gets a COVID vaccine first? Access plans are taking shape. Nature. 24 Sep 2020; 585(7826): 492-3.