Development, characterization, in vitro and ex vivo evaluation of antiemetic transdermal patches of ondansetron hydrochloride and dexamethasone
DOI:
https://doi.org/10.30574/gscbps.2021.14.3.0061Keywords:
Transdermal drug delivery, Transdermal patches, Ondansetron HCl, Dexamethasone, Ex vivo etc.Abstract
The idea of delivering drugs through skin is old, as the use is reported back in 16th century B.C. The husk of the castor oil plant in water was placed on an aching head. Today the transdermal drug delivery is well accepted for delivering drugs to the systemic circulation. The aim of this study was to design a compound transdermal patches containing ondansetrone HCL and dexamethasone for the treatment of nausea and vomiting in case of chemotherapy and regular symptom of nausea and vomiting. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Ondansetron-HCl and Dexamethasone in different ratios of hydrophilic and hydrophobic polymeric combinations with 15% w/v plasticizer and 5% w/v penetration enhancer were mixed with the polymer solution polymer were using solvent evaporation technique. The patches were further subjected to various characterization studies for prepared transdermal patches along with the thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, In vitro drug permeation study on Franz diffusion cells. Obtained results showed no physical-chemical incompatibility between drugs and polymers. On the basis of results obtained from, tensile strength (18±0.16), folding endurance (126 ± 1 to 68 ± 2), % moisture content (2.9±0.4), % moisture uptake, % drug content (92.41 to 98.9 %), TPEC (Transdermal Patches of Ethyl Cellulose) was selected as optimized formulation. In vitro release of the selected batch, TPEC-1 followed by zero-order and formulation showed 62.69 % drug diffusion within 10 hours. Conclusively, the patches were considered to deliver drugs safely through the skin for a longer period often.
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Harper, Mary Lea. Pharmacist's Drug Handbook. American Journal of Pharmaceutical Education. 2001; 65(3): 302.
Keith, Alec D. Polymer matrix considerations for transdermal devices. Drug development and industrial pharmacy. 1983; 9(4): 605-625.
Chien, Yie W. Development of transdermal drug delivery systems. Drug development and industrial pharmacy. 1987; 13(4-5): 589-651.
Misra AN. Transdermal drug delivery. Controlled and novel drug delivery, 1st ed. New Delhi: CBS Publishers and Distributors. 1997; 100-29.
Chien YW, GA Patani. Transdermal drug delivery devices: system design and composition. Encyclopedia of Pharmaceutical Technology. 1999; 18: 309-337.
Butcher ME. Global experience with ondansetron and future potential. Oncology. 1993; 50(3): 191-197.
McKenzie, Ray, Anthony Kovac, Thomas O'Connor, Deryck Duncalf, John Angel, Irwin Gratz, Eugene Tolpin, Charles McLeskey, Alan Joslyn. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology: The Journal of the American Society of Anesthesiologists. 1993; 78(1): 21-28.
Scuderi, Phillip, Bernard Wetchler, Yung-Fong Sung, Melinda Mingus, Stuart DuPen, Louis Claybon, Pekka Talke, Jeffrey Apfelbaum, Said Sharifi-Azad, Melissa F. Williams. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology: The Journal of the American Society of Anesthesiologists. 1993; 78(1): 15-20.
Hesketh, Paul J, David R. Gandara. Serotonin antagonists: a new class of antiemetic agents. JNCI: Journal of the National Cancer Institute. 1991; 83(9): 613-620.
Bozigian Haig P, J Frederick Pritchard, Ann E. Gooding, Gary E. Pakes. Ondansetron absorption in adults: effect of dosage form, food, and antacids. Journal of pharmaceutical sciences. 1994; 83(7): 1011-1013.
Hsyu, Poe-Hirr, J Frederick Pritchard, Haig P Bozigian, Thomas L Lloyd, Rita H Griffin, Robert Shamburek, Gopal Krishna, William H. Barr. Comparison of the pharmacokinetics of an ondansetron solution (8 mg) when administered intravenously, orally, to the colon, and to the rectum. Pharmaceutical research. 1994; 11(1): 156-159.
Hussain Anwar A, Adnan Dakkuri, Soichi Itoh. Nasal absorption of ondansetron in rats: an alternative route of drug delivery. Cancer chemotherapy and pharmacology. 2000; 45(5): 432-434.
Gwak Hye Sun, Ik Sang Oh, In Koo Chun. In vitro percutaneous absorption of ondansetron hydrochloride from pressure-sensitive adhesive matrices through hairless mouse skin. Archives of pharmacal research. 2003; 26(8): 644-648.
Chandra, Amrish, Pramod Kumar Sharma, Raghuveer Irchhiaya. Microemulsion-based hydrogel formulation for transdermal delivery of dexamethasone. Asian Journal of Pharmaceutics (AJP). 2014; 3(1).
Kobayashi, Ichiro, Kyoko Hosaka, Hiroki Maruo, Yuji Saeki, Masashi Kamiyama, Chohachi Konno, Munekazu Gemba. Role of prostaglandin E2 and leukotriene B4 in skin reaction induced by transdermal application of propranolol. Biological and Pharmaceutical Bulletin. 2000; 23(2): 208-212.
Slayden SM, L Crabbe, S Bae, HD Potter, Ricardo Azziz, CR Parker Jr. The effect of 17β-estradiol on adrenocortical sensitivity, responsiveness, and steroidogenesis in postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 1998; 83(2): 519-524.
Fischer, DuncanK, RichardK Simpson F. Ames Smith, and KennethL Mattox. "Efficacy of dexamethasone in benzodiazepine-resistant delirium tremens." The Lancet. 1988; 331(8598): 1340-1341.
Heath, Donald, David Reid Williams. High-altitude medicine and pathology. Oxford University Press, USA. 1995.
Mantovani G, L Curreli, A Maccio, Elena Massa D Massa, C Mulas, G Succu, Paolo Contu. Prevention of nausea and vomiting (N&V) in cancer patients receiving high-dose cisplatin. Assessment of the potential antiemetic activity of transdermal fentanyl (TTS-F) compared to standard antiemetic treatment in acute and delayed N&V: first clinical report." Anticancer research. 1999; 19(4C): 3495-3502.
Nagashima M, K Wauke, D Hirano, S Ishigami, H Aono, M Takai, M Sasano, S Yoshino. Effects of combinations of anti‐rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis. Rheumatology. 2000; 39(11): 1255-1262.
Tsuei S Edmund, R George Moore, John J Ashley, William G McBride. Disposition of synthetic glucocorticoids I. Pharmacokinetics of dexamethasone in healthy adults." Journal of pharmacokinetics and biopharmaceutics. 1979; 7(3): 249-264.
Arora Priyanka, Biswajit Mukherjee. Design, development, physicochemical, and In vitro and In vivo evaluation of transdermal patches containing diclofenac diethylammonium salt." Journal of pharmaceutical sciences. 2002; 91(9): 2076-2089.
Ramkanth S, Alagusundaram M, Chetty M, Gnanprakash K. International journal of pharma research. 2009; 88-91.
Amnuaikit, Chomchan, Itsue Ikeuchi, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. International journal of pharmaceutics. 2005; 289(1-2): 167-178.
Gupta R, M Bajpai, A Bhattacharya. Formulation and In vitro evaluation of transdermal drug delivery system of tizanidine hydrochloride." Indian Journal of Pharmaceutical Sciences. 2008; 7(4).
Kusum Devi V, S Saisivam, GR Maria, PU Deepti. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug development and industrial pharmacy. 2003; 29(5): 495-503.
Hiremath, Shobha Rani R. Cytotoxicity, anti-tumor activity, cumulative skin irritation and sensitization study of 5-fluorouracil from a transdermal patch for dalton's lymphoma ascites cells. Journal of health science 53, no. 3 (2007): 275-281.Shaila L, Pandey S, Udupa N. Indian J. Pharm. Sci. 2006; 68(2): 179-184.
Lewis, Shaila, N. Udupa. Design and evaluation of matrix type and membrane controlled transdermal delivery systems of nicotine suitable for use in smoking cessation. Indian journal of pharmaceutical sciences. 2006; 68(2).
Arijit D, G Sibaji, KD Biplab, D Sudip. A novel technique for treating the type ll diabetes by transdermal patches prepared by using multiple polymer complexes. Int J Pharma Res Dev. 2010; 9: 195-204.
Deshmane, Subhash V, Madhuri A Channawar, Anil V Chandewar, Unmesh M Joshi, Kailash R Biyani. Chitosan based sustained release mucoadhesive buccal patches containing verapamil HCl. Int. J. Pharm. Pharm. Sci. 2009; 1(1): 216-229.
Garala, Kevin C, Anil J Shinde, Pratik H. Shah. Formulation and in-vitro characterization of monolithic matrix transdermal systems using HPMC/Eudragit S 100 polymer blends." Int J Pharm Pharm Sci. 2009; 1(1): 108-20.
Patel Hemangi J, Jitendra S Patel, BG Desai, Keyur D Patel. Design and evaluation of amlodipine besilate transdermal patches containing film former. Int J Pharma Res Dev. 2009; 7(1).
Thenge RR, Mahajan KG, Sawarkar HS, Adhao VS, Gangane PS. Formulation and Evaluation Of Transdermal Drug Delivery System For Lercanidipine Hydrochloride Int J. PharmTech Res. Jan-Mar 2010; 2(1): 253-258.
Ubaidulla U, Reddy MV, Rukmani K, Ahmad FJ, Khar RK. AAPS pharma. Sci. Tech. 2007; 8(1): 212-216.
GT Burger, L Cheryl Miller. in: A. Wallace Hayes (Ed.), Principles and Methods of Technology, Raven Press, New York. 1989; 521– 570.
Sarpotdar Pramod P, James L Gaskill, Robert P. Giannini. Effect of polyethlene glycol 400 on the penetration of drugs through human cadaver skin in vitro. Journal of pharmaceutical sciences. 1986; 75(1): 26-28.
Gupta Ritu, Biswajit Mukherjee. Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone–ethylcellulose matrices." Drug development and industrial pharmacy. 2003; 29(1): 1-7.
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