Leucas zeylanica is a Bangladeshi plant with significant medicinal prospect: A review

Md. Islam  Molla; Sabiha Parvin  Ela

doi:10.30574/gscbps.2021.16.1.0184

Authors

Md. Islam Molla Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh.
Sabiha Parvin Ela Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh.

DOI:

https://doi.org/10.30574/gscbps.2021.16.1.0184

Keywords:

Leucas zeylanica, Folkloric system, Phytoconstituents, Pharmacological activities, Lead compounds

Abstract

Leucas zeylanica is one of the most precious gifts of nature to the entire civilization. It offers folkloric system a dependable option to heal numerous diseases like- burning urination, toothaches, common skin diseases, gout, inflammatory conditions, rheumatic diseases, abdominal pain, worms, anorexia, colic, flatulence, etc. Many of these ancient practices have got their scientific resemblances like- using as an agent for treating common pains, oxidative stresses, microbial infections, sleep disorders, inflammations, gout associated pains, thrombosis and sunlight related skin damages. Some researchers also isolated a huge bunch of vital phytochemicals like- torosaﬂavone A, drymariatin C, daidzein, luteolin 3′,4′-dimethyl ether, apigenin, tricin, chrysoeriol, linarigenin, β-sitosterol, stigmasterol, hexadecanoic acid, octadecanoic acid, 9,12,15- octadecatrienoic acid, farnesene, β-caryophyllene, caryophyllene oxide, phytol, β-cubebene, α-selinene, α-tocopherol etc. from different crude extracts of Leucas zeylanica. Making proper correlation between these phytoconstituents with the general utilizations of this plant will assist scientists to develop auspicious lead compounds. This review covers a summary of ethnomedicinal, phytochemical and biological studies of several crude preparations of Leucas zeylanica.

Metrics

Metrics Loading ...

References

Rafe MR, Ahsan M, Hasan CM, Masud MM. Chemical and Biological Studies of Leaf Extract of Dendrophthoe falcata Linn. Dhaka University Journal of Pharmaceutical Sciences. 2017; 16(2): 215-219.

Prabhadevi V, Sahaya SS, Johnson M, Venkatramani B, Janakiraman N. Phytochemical studies on Allamanda cathartica L. using GC–MS. Asian Pacific Journal of Tropical Biomedicine. 2012; 2(2): S550-554.

Muhammad A. Therapeutic flora in Holy Quran. African Journal of History and Culture. 2014; 6(9): 141-148.

Dhar AS, Rahman M, Rafe MR, Molla MI. Assessment of antidepressant and sedative-hypnotic activities of methanolic crude extracts of Stephania japonica (Thunb.) Miers. Whole plants. Current Issues in Pharmacy and Medical Sciences. 2020; 33(1): 51-55.

Chouhan HS, Singh SK. A review of plants of genus Leucas. Journal of Pharmacognosy and Phytotherapy. 2011; 3(3): 13-26.

Jebin R, Molla MI, Chowdhury SM, Rafe MR. Antidepressant and sedative-hypnotic activities of methanolic extract of grewia asiatica Linn. Leaves in Mice. Bangladesh Pharmaceutical Journal. 2019; 22(2): 185-191.

Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life sciences. 2005; 78(5): 431-441.

Yamamoto J, Yamada K, Naemura A, Yamashita T, Arai R. Testing various herbs for antithrombotic effect. Nutrition. 2005; 21(5): 580-587.

Li Z, Wang H, Li J, Zhang G, Gao C. Basic and clinical study on the antithrombotic mechanism of glycosaminoglycan extracted from sea cucumber. Chinese Medical Journal. 2000; 113(8): 706-711.

Briggs WH, Folts JD, Osman HE, Goldman IL. Administration of raw onion inhibits platelet-mediated thrombosis in dogs. The Journal of nutrition. 2001; 131(10): 2619-2622.

Demrow HS, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation. 1995; 91(4): 1182-1188.

Hedge IC. Labiatae. In: Flora of Pakistan. Ali SI, Nasir YJ (Ed). University of Karachi, Karachi. 1990; 192.

Khanam M, Hassan MA. A critical study of the genus Leucas R. Br. (Lamiaceae) from Bangladesh. Bangladesh Journal of Plant Taxonomy. 2005; 12(1): 1-10.

Jayaweera, DMA. Medicinal plants (Indigenous and exotic) used in Ceylon, Part III. National Science Council, Sri Lanka. 1980.

Babu A, Mohamed MS, Jaikumar K, Anand D, Saravanan P. In-vitro antifungal activity of leaf extracts of Leucas aspera and Leucas zeylanica. International Journal of Pharmaceutical Sciences and Research. 2016; 7(2): 752.

Uddin MZ, Emran TB, Nath AK, Jenny A, Dutta M, Morshed M. Thrombolytic activities of Spilanthes calva and Leucas zeylanica. Mol Clin Phol. 2013; 4: 32-37.

Yusuf M, Wahab MA, Yousuf MD, Chowdhury JU, Begum J. Some tribal medicinal plants of Chittagong hill tracts, Bangladesh. Bangladesh Journal of Plant Taxonomy. 2007; 14(2): 117-128.

Rajakaruna N, Harris CS, Towers GH. Antimicrobial activity of plants collected from serpentine outcrops in Sri Lanka. Pharmaceutical Biology. 2002; 40(3): 235-244.

Harborne JB, Baxter H, Moss GP. Phytochemical dictionary: A handbook of bioactive compounds from plants. London: Tylor & Francis Ltd. 1993; 773.

Chopra RN, Nayar SL, Chopra IC. In Glossary of Indian medicinal plants, National Institute of Science Communication, New Delhi, India, 169 Cragg, GM and Newman, DJ (2005). Plants as a source of anticancer agents. J Ethnopharmacology. 1996; 100(1-2): 72-79.

CAIUS JF. The medicinal and poisonous plants of India. Scientific Publications, Jodhpur, India. 1986.

Ediriweera S. Effect of decoction of Leucas zeylanica in worm infestation with special reference to Enterobius vermicularis. Journal of Ayurveda and Holistic Medicine (JAHM). 2014; 2(3): 11-17.

Jain D, Baheti AM, Jain SR, Khandelwal KR. Use of medicinal plants among tribes in Satpuda region of Dhule and Jalgaon district of Maharastra- An ethnobotanical survey. Indian J. Tradit. Know. 2010; 9: 152-157.

Yusuf M, Wahab MA, Yousuf MD, Chowdhury JU, Begum J. Some tribal medicinal plants of Chittagong hill tracts, Bangladesh. Bangladesh Journal of Plant Taxonomy. 2007; 14(2): 117-128.

Yusuf M, Wahab MA, Chowdhury JU, Begum J. Ethno-medico-botanical knowledge from Kaukhali proper and Betbunia of Rangamati District. Bangladesh Journal of Plant Taxonomy. 2006; 13(1): 55-61.

Shirazi AM. Studies on Leucas aspera. Indian j pharm. 1947; 9: 116-117.

Ghani A. Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh, Dhaka, Bangladesh. 1998.

Trease GE, Evans WC. A Text Book of Pharmacognosy. 13th ed. Cambridge University Press. London, England. 1989; 546.

Paul S, Saha D. Pharmacognostic studies on methanolic extract of the aerial part of Leucas zeylanica. Asian J Pharm Res. 2012; 2: 142–143.

Radhika B, Srilekha T, Chaitanya S. Pharmacognostic and Preliminary Phytochemical Evaluation of the leaves of Lucas zeylanica. Int J Biomed Investig. 2018; 1: 102.

Napagoda M, Gerstmeier J, Butschek H, Lorenz S, Kanatiwela D, Qader M, Nagahawatte A, De Soyza S, Wijayaratne GB, Svatoš A, Jayasinghe L. Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout. Journal of ethnopharmacology. 2018; 224: 474-481.

Zhang X, Gui M, Zhang C, Chen C, Yu L, Liu J. Leucasinoside: A new abietane diterpenoid glycoside from Leucas zeylanica. Records of Natural Products. 2016; 10(5): 645.

Chen GY, Zhang B, Zhao T, Nidhal N, Jia-Li W, Zhou XM, Chun-Yan D. A new triterpenoid glucoside from Leucas zeylanica. Natural product research. 2020; 34(13): 1874-1878.

Tian GH, Liu CF, Wei C, Lai PH. Study on Essential Oil Obtained from the Seed of Leucas zeylanica [J]. Amino Acids & Biotic Resources. 2009; 2.

Nidhal N, Zhou XM, Chen G, Zhang B, Han C, Song X. Chemical constituents of Leucas zeylanica and their chemotaxonomic significance. Biochemical Systematics and Ecology. 2020; 89: 104006.

Islam MM, Parvin ES, Zahir RS, Al MZ. Methanolic extracts and different fractions of whole plants of Leucas zeylanica show promising analgesic and antioxidative activities. Egyptian Pharmaceutical Journal. 2020; 19(3): 260-265.

Ahmed M, Shikha HA, Sadhu SK, Rahman MT, Datta BK. Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis. Die Pharmazie. 2001; 56(8): 657-660.

Pizziketti RJ, Pressman NS, Geller EB, Cowan A, Adler MW. Rat cold water tail-flick: a novel analgesic test that distinguishes opioid agonists from mixed agonist-antagonists. European journal of pharmacology. 1985; 119(1-2): 23-29.

Islam MA, Biswas NN. Assessment of phytochemical and pharmacological activities of Leucas zeylanica (L) R. Br. (Family: Lamiaceae). Hamdard Medicus. 2010; 53: 19–29.

Hossain S, Rahman M, Fatima N, Haque M, Islam J. Leucas zeylanica (L.) R. Br. protects ethanol and hydrogen peroxide-induced oxidative stress on hepatic tissue of rats. International Current Pharmaceutical Journal. 2013; 2(9): 148-151.

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin-phenol reagent. Journal of biological chemistry. 1951; 193: 265-275.

Brand-Williams W, Cuvelier ME, Berset CL. Use of a free radical method to evaluate antioxidant activity. LWT-Food science and Technology. 1995; 28(1): 25-30.

Gupta M, Mazumdar UK, Sivahkumar T, Vamis ML, Karki S, Sambathkumar R, Manikandan L. Antioxidant and anti-inflammatory activities of Acalypha fruticosa. Nigerian Journal of Natural Products and Medicine. 2003; 7: 25-29.

Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic Susceptibility Testing by a Standardized Single Disk Method. American journal of clinical pathology. 1966; 45(4): 493-496.

Ahmed F, Das PK, Islam MA, Rahman KM, Rahman MM, Selim MS. Antibacterial activity of Cordyline terminalis. Kunth. Leaves. J. Med. Sci. 2003; 3(5-6): 418-422.

Andrews JM. Determination of minimum inhibitory concentrations. Journal of antimicrobial chemotherapy. 2001; 48(1): 5-16.

Eldeen IM, Van Staden J. Antimycobacterial activity of some trees used in South African traditional medicine. South African Journal of Botany. 2007; 73(2): 248-251.

Abdullah F, Nasir SN, Han DK, Appalasamy S, nor MM, Rak AE. Potential of Leucas zeylanica extract to eliminate E. coli and S. aureus in Corbicula fluminea (“Etak”) tissue. Malaysian Journal of Fundamental and Applied Sciences. 2019; 15(4): 597-599.

Chatterjee TK. Handbook of laboratory Mice and Rats, 1st Edition. Department of Pharmaceutical Technology, Jadavpur University, India. 1993; 157.

Dandiya PC, Cullumbine H. Studies on Acorus calamus (III): some pharmacological actions of the volatile oil. Journal of Pharmacology and Experimental Therapeutics. 1959; 125(4): 353-359.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. Journal of medicinal chemistry. 2008; 51(24): 8068-8076.

Werz O. Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. Planta medica. 2007; 73(13): 1331-1357.

Fischer L, Szellas D, Rådmark O, Steinhilber D, Werz O. Phosphorylation‐and stimulus‐dependent inhibition of cellular 5‐lipoxygenase activity by nonredox‐type inhibitors. The FASEB journal. 2003; 17(8): 1-24.

Koeberle A, Werz O. Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders. Biochemical pharmacology. 2015; 98(1): 1-15.

Khan KM, Khan M, Karim A, Taha M, Ambreen N, Gojayev A, Perveen S, Choudhary MI. Xanthine oxidase inhibition by 5-aryledene N, N′-dimethylbarbituric acid derivatives. J Chem Soc Pak. 2013; 35: 495-498.

Uddin MZ, Emran TB, Nath AK, Jenny A, Dutta M, Morshed M. Thrombolytic activities of Spilanthes calva and Leucas zeylanica. Mol Clin Phol. 2013; 4: 32-37.

Prasad S, Kashyap RS, Deopujari JY, Purohit HJ, Taori GM, Daginawala HF. Effect of Fagonia arabica (Dhamasa) on in vitro thrombolysis. BMC Complementary and Alternative Medicine. 2007; 7(1): 1-6.

Napagoda MT, Malkanthi BM, Abayawardana SA, Qader MM, Jayasinghe L. Photoprotective potential in some medicinal plants used to treat skin diseases in Sri Lanka. BMC complementary and alternative medicine. 2016 16(1): 1-6.

Mansur JS, Breder MN, Mansur MC, Azulay RD. Determination of sun protection factor by spectrophotometry. A Bras Dermatol. 1986; 61: 121–124.