Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity

Mina  Hariri; Fatemeh  Darvish; Karen-Pacelye Mengue Me  Ndong; Rachida  Babouri; Jacques  Lebibi; Gabin Mwande- Maguene; Alexander R  Burilov; Patricia  Licznar-Fajardo; Jean-Luc  Pirat; Tahar  Ayad; David  Virieux

doi:10.30574/gscbps.2021.16.2.0252

Authors

Mina Hariri ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
Fatemeh Darvish Department of Chemistry, K. N. Toosi University of Technology, P.O. Box, 15875-4416 Tehran, Iran.
Karen-Pacelye Mengue Me Ndong Université des Sciences et Techniques de Masuku, Franceville, Gabon.
Rachida Babouri ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
Jacques Lebibi Université des Sciences et Techniques de Masuku, Franceville, Gabon.
Gabin Mwande- Maguene Université des Sciences et Techniques de Masuku, Franceville, Gabon.
Alexander R Burilov Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, Kazan 420088, Russian Federation.
Patricia Licznar-Fajardo Hydro Sciences Montpellier, Univ Montpellier, CNRS, IRD, CHU Montpellier, Montpellier, France.
Jean-Luc Pirat ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
Tahar Ayad ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
David Virieux ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.

DOI:

https://doi.org/10.30574/gscbps.2021.16.2.0252

Keywords:

Isophosphinoline-2-oxides, Phosphacoumarins, Synthesis, Antibacterial activities

Abstract

The present study aims to investigate the in vitro antibacterial activities of several isophosphinoline-2-oxides that can be perceived as combined bio isosteres of coumarins and flavonoids. More specifically, antibacterial activity was evaluated against four bacterial strains, including the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and the Gram-positive bacteria Staphylococcus aureus and Enterococcus faecalis by using disk diffusion assay. Notably, isophosphinoline-2-oxide compounds showed promising and highly selective antimicrobial activity against S. aureus

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