Evaluation of toxicological profile of methanol leaf extract of Waltheria indica (Sterculiaceae)

Oluwasegun  Adedokun; Ogochukwu  Ume; Mansurat  Odunola; Didacus  Nnamani; Christiana  Jesumirhewe; Toluwalope  Ojo; Ifeatu  Aniebue

doi:10.30574/gscbps.2021.17.2.0267

Authors

Oluwasegun Adedokun Department of Pharmacognosy, Igbinedion University, Okada, Edo State, Nigeria.
Ogochukwu Ume Department of Pharmaceutical Chemistry, Igbinedion University, Okada, Edo State, Nigeria.
Mansurat Odunola Department of Pharmacognosy, Igbinedion University, Okada, Edo State, Nigeria.
Didacus Nnamani Department of Pharmaceutical technology, Igbinedion University, Okada, Edo State, Nigeria.
Christiana Jesumirhewe Department of Pharmaceutical microbiology, Igbinedion University, Okada, Edo State, Nigeria.
Toluwalope Ojo Department of Pharmacognosy, Igbinedion University, Okada, Edo State, Nigeria.
Ifeatu Aniebue Department of Pharmacognosy, Igbinedion University, Okada, Edo State, Nigeria.

DOI:

https://doi.org/10.30574/gscbps.2021.17.2.0267

Keywords:

Acute toxicity, Biochemical parameters, Sub-acute toxicity, W. indica

Abstract

Waltheria indica has been claimed to be used in managing several diseases in traditional medicine, although substantial scientific data are not available as regards its safety despite its pronounced efficacy in management of some ailments. Therefore, methanol leaf extract of W. indica was evaluated for its effects on some toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out using experimental animals as described by standard methods. Absence of death reported after 24 hours of single oral administration of W. indica indicated that the crude drug is safe orally and the sample also had no effect on both hematological and biochemical parameters, with mild toxicity observed with some vital enzymes and organs upon continuous oral administration of W. indica for 21 days. However, it can be concluded that prolong usage of the plant for disease management should be discouraged, which implies that usage of the pant for short time usage in disease management.

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