A review on cubosome: The novel drug delivery system

Venkateswara Rao Sadhu; Naga Sravya Beram; Padmalatha Kantamneni

doi:10.30574/gscbps.2018.5.1.0089

Authors

Venkateswara Rao Sadhu Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.
Naga Sravya Beram Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.
Padmalatha Kantamneni Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.

DOI:

https://doi.org/10.30574/gscbps.2018.5.1.0089

Keywords:

Cubosomes, Nanoparticles, Bicontinuous, Honeycomb

Abstract

Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in definite proportion, known as bicontinuous cubic phase liquid crystals. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. They perform solid like rheology with unique properties of practical interest. They are thermodynamically stable and they have carvenous (honeycomb) structures which are tightly packed twisted into three dimensional bilayers. This type of complex structure allows them to have greater drug loading ability. Cubosomes have ability to encapsulate the hydrophobic, hydrophilic, amphiphilic substances. Cubosomes can increase the solubility of poorly soluble drug. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, light scattering, x-ray and NMR, nevertheless few researchers has been studying the potential of cubosome as delivery systems.

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References

Almeida JD, Brand CM, Edwards DC and Heath TD (1975). Formation of virosomes from influenza subunits and liposomes. Lancet. 2, 899-901.

Spicer PT. (2004). Cubosomes bicontinuous cubic liquid crystalline nanostructured particles. The Procter and Gamble Company, West Chester, Ohio, USA.

Rizwan SB, Dong YD, Boyd BJ, Rades T and Hook S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy. Micron. 38, 478–485.

Tilekar KB, Khade PH, Kakade S, Kotwal S and Patil R. (2014). Cubosomes a drug delivery system. International Journal of Chemical and Biochemical Science. 4, 812-824.

Karami Z and Hamidi M. (2016). Cubosomes: Remarkable drug delivery potential. Drug Discovery Today. 21, 789–801.

Urvi S, Dhiren D, Bhavin P, Patel U and Shah R. (2013). Overview of cubosomes: A Nanoparticle. In. J of Ph. and Integ. Life Sci., 1(5), 36-47.

Stroem P and Anderson DM. (1992). The cubic phase region in the system didodecyl dimethyl ammonium bromide-water-styrene. Langmuir. 8(2), 691-709.

Engström S, Larsson K and Lindman B. (1998). Controlled Release Bioact. Mater. 15, 105—106.

Bhowmik D, Gopinath H, Kumar BP, Duraivel S and Kumar KS. (2012). Recent advances in novel topical drug delivery system. The Pharma Innovation. 1(9), 12.

Thorat YS, Gonjari ID and Hosmani AH. (2011). Solubility enhancement techniques: a review on conventional and novel approaches. International journal of pharmaceutical sciences and research. 2(10), 2501.

Bhosale RR, Osmani RA, Harkare BR and Ghodake PP. (2013). The Inimitable Nanoparticulate Drug Carriers. Scholars Academic Journal of Pharmacy. 2(6), 481-486.

Saly S, Ehab RB and Sabry B. (2013). The design and evaluation of novel encapsulation technique for topical application of alpha lipoic acid. Journal of Advanced Pharmaceutical Research. 4(1), 13-22.

Sagnella S and Drummond C. (2012). Drug delivery a nanomedicine approach. Australian Biochemist. (43), 5-7.

Bei D, Meng J and Youan BC. (2010). Engineering nanomedicines for improved melanoma therapy progress and promises. Nanomedicine (London, England), 5(9), 1385-1399.

Angelov B, Angelova A and Garamus VM. (2012). Earliest stage of the tetrahedral nanochannel formation in cubosome particles from unilamellar nanovesicles. Langmuir. 28(48), 16647–16655.

Angelov B, Angelova A and Drechsler M. (2015). Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo- TEM imaging. Soft Matter. 11(18), 3686–3692.

Thadanki M, Kumari PS and Prabha KS. (2011). Overview of cubosomes: a nanoparticle. International Journal of Research in Pharmacy and Chemistry. 1(3), 535-541.

Angelova A, Angelov B and Lesieur S. (2008). Dynamic control of nanofluidic channels in protein drug delivery vehicles. Journal of Drug Delivery Science and Technology. 18(1); 41–45.

Angelova A, Angelov B and Drechsler M. (2013). Protein entrapment in PEGylated lipid nanoparticles. International Journal of Pharmac. 454(2), 625–632.

Wibroe PP, Azmi ID, Nilsson C, Yaghmur A and Moghimi SM. (2015). Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: towards development of safe tunable intravenous lipid nanocarriers. Nanomedicine. 11(8), 1909–1914.