Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Amos Ndarubu Tsado; Stella Chiamaka Onukogu; Alfa Suleiman; Aishatu Mustapha; Ekeoma Chinedu Osuigwe; Luke Wenawo Dannana; Rhamatalah Adenike Alawode; Bashir Lawal; Bonghan Eustace Berinyuy

doi:10.30574/gscbps.2019.8.3.01170

Authors

Amos Ndarubu Tsado Department of Biological Sciences, Niger State Polytechnic Zungeru, P.M.B 001, Zungeru, Niger State.
Stella Chiamaka Onukogu Department of Biochemistry, Federal University of Technology Minna, P.M.B. 65, Nigeria.
Alfa Suleiman Department of Biological Sciences, Federal Polytechnic Bida, Nigeria.
Aishatu Mustapha Department of Microbiology, Federal University of Technology Minna, P.M.B. 65, Nigeria.
Ekeoma Chinedu Osuigwe Department of Biochemistry, Federal University of Technology Minna, P.M.B. 65, Nigeria.
Luke Wenawo Dannana Department of Biochemistry, Federal University of Technology Minna, P.M.B. 65, Nigeria.
Rhamatalah Adenike Alawode Forestry research institute of Nigeria-Southern Guinea Research Station, Mokwa, Niger State, Nigeria.
Bashir Lawal Department of Biochemistry, Federal University of Technology Minna, P.M.B. 65, Nigeria.
Bonghan Eustace Berinyuy Faculty of medicine and biomedical sciences, University of Yaounde 1, Yaounde, Cameroon.

DOI:

https://doi.org/10.30574/gscbps.2019.8.3.01170

Keywords:

Hibiscus sabdariffa, Phytochemicals, Hyperglycemia, Diabetes

Abstract

This study investigates the phytochemicals, antidiabetic and hypolipidemic activities of Hibiscus sabdariffa methanol leaves extract in alloxan induced diabetic wistar rat by administering graded oral doses (100, 200 and 400 mg/kg body weight) for 21 days. Results revealed that the methanol leaf extract of Hibiscus sabdariffa contains 51.90±3.89 mg/100g of tannins, 102.56±6.89 mg/100g of saponins, 54.78±3.89 mg/100g of alkaloids, 67.45±3.87 mg/100g of flavonoids and 121.54±5.67 mg/100g of phenols. The extract showed dosed dependent significant (p<0.05) antidiabetic activity with significant improvement in body weight. The extract also resulted in significant (p<0.05) reduction serum cholesterol, triglycerides. LDL-cholesterol level and increase HDL-cholesterol when compared with untreated control. In conclusion, this study demonstrates, for the first time, that Hibiscus sabdariffa is effective in inhibiting hyperglycemia and dyslipidemia in diabetes condition.

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