Formulation and Evaluation of the sea cucumber, Holothuria arenicola extract incorporated skin cream

Ayman Saber Mohamed; Sohair Ramadan Fahmy; Abdelaziz A. Elsayed

doi:10.30574/gscbps.2020.13.2.0379

Authors

Ayman Saber Mohamed Zoology Department - Faculty of Science - Cairo University, Egypt
Sohair Ramadan Fahmy Zoology Department - Faculty of Science - Cairo University, Egypt
Abdelaziz A. Elsayed Department of Zoology, Faculty of Science, Zagazig University, Egypt.

DOI:

https://doi.org/10.30574/gscbps.2020.13.2.0379

Keywords:

Holothuria arenicola, Antioxidant, Cream, skin

Abstract

Background: Cucumber extract is often used for skin problems, wrinkles, sunburn, and as an antioxidant. Thereby, the main objective of the present investigation was to develop a topical skincare cream (w/o) loaded with the sea cucumber, Holothuria arenicola extract (HaE).

Methods: Oil in water emulsion-based cream was prepared by incorporating liquid paraffin, soft wax, cetostearyl alcohol in the oil phase, and borax in the water phase respectively with 1 gm of HaE. The evaluation of HaE cream was done on different parameters like ph, viscosity, spreadability, extrudability, irritancy and stability.

Results: HaE showed good appearance, homogeneity, spreadability, diffusion, consistency, pH, extrudability, and spreadability without any irritancy to skin. The present results showed that HaE cream has radical scavenging activity in range from 57 to 70 % and NO scavenging activity in range from 25 to 49 %. Conclusion: The formulated HaE cream was successfully developed that met the relevant pharmaceutical characteristics form. The developed HaE cream could be added in topical formulations in order to protect skin against damage caused by free radicals due to its antioxidant activity.

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