Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats

Ayman Saber Mohamed; Mohamed Abdelmohsen Gamal; Emad El-Zayat; H Suliman

doi:10.30574/gscbps.2021.14.3.0069

Authors

Ayman Saber Mohamed Physiology- Zoology Department - Faculty of Science - Cairo University -12613, Giza, Egypt. Tel: 01275350954.
Mohamed Abdelmohsen Gamal Department of biotechnology, University for Modern Sciences and Arts (MSA), Egypt.
Emad El-Zayat Molecular Physiology and Biotechnology, Zoology Department, Faculty of Sciences, Cairo University, Egypt.
H Suliman Medical Biochemistry, Faculty of Medicine, Alexandria University, Egypt.

DOI:

https://doi.org/10.30574/gscbps.2021.14.3.0069

Keywords:

Holothuria Arenicola, Saponin, Gentamycin, Hepatorenal toxicity, Oxidative stress

Abstract

Background: Sea cucumbers have number of one of a pharmacological effects counting anticancer, anticoagulant, anti-inflammatory, antioxidant, and wound healing. Biological properties and therapeutic benefits of Sea cucumbers can be connected to the presence of a wide cluster of bioactive compounds particularly triterpene glycosides (saponins). Aims: The present study aimed to explore the hepatoprotective and nephroprotective activity of Sea cucumbers-saponin (Sc-S) on gentamicin-induced hepatorenal toxicity in rats. Main methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and gentamycin+ Sc-S. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, i.p) for 8 days. Results: The Sc-S group showed a reduction in the concentrations of urea, uric acid, creatinine, MDA and the activities of AST, ALT, and ALP. While it caused a general increase in the levels of CAT and GSH. Microscopic examination appeared a clear enhancement in liver and kidney histology of Sc-S group. Conclusion: The antioxidant activity of Sc-S is the main mechanism for the protection of the liver and kidney against gentamicin toxicity.

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