Review on various factors responsible for neurodegenerative disorders

Harshwardhan J  Tembhurnikar; Neha D  Thool; Rasika J  Patil; Ranjita K  Das

doi:10.30574/gscbps.2021.16.1.0203

Authors

Harshwardhan J Tembhurnikar Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur-441 002, Maharashtra, India
Neha D Thool Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur-441 002, Maharashtra, India
Rasika J Patil Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur-441 002, Maharashtra, India
Ranjita K Das Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur-441 002, Maharashtra, India

DOI:

https://doi.org/10.30574/gscbps.2021.16.1.0203

Keywords:

Oxidative stress, Mitochondrial dysfunction, Neurodegeneration, Excitotoxicity

Abstract

Neurodegenerative disorders are nervous system disorders that result in the loss of neuronal structure and function. As shown in Alzheimer's and Parkinson's disease, these changes cause a loss of various capacities, including cognition and mobility. Several factors have been discovered to play a critical role in the etiology of common neurological illnesses, including oxidative stress and protein misfolding. It's still unclear if these factors cause or contribute to the progression of the illnesses. Despite efforts to understand the molecular and pathophysiological mechanisms behind these pathways, many aspects remain unknown. The goal of this review is to investigate the numerous factors linked to neurodegeneration.

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