Development and evaluation of Pharmacosome formulations of Mefenamic acid

Authors

  • Gurleen Kaur Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
  • Kirti Negi Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
  • Kapil Kumar Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
  • Deepak Teotia Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.

DOI:

https://doi.org/10.30574/gscbps.2021.16.3.0286

Keywords:

Pharmacosomes, Mefenamic Acid, Topical delivery, Monorrhagia, Gynecological disorder

Abstract

Patience who suffered from menstrual pain disease is generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Monorrhagia or another blood disorder & some gynecological disorder, which impairs body function and acts as an economic burden. Due to respective use of ACE by oral route, it may cause GI complication such as bleeding, pain, perforation, abdominal pain, and swelling. To decrease the side effect of ACE, it is given by topical route in promotes the safety & efficacy of the ACE. The Mefenamic Acid pharmacosomes were prepared by the hand shaking method technique and evaluated by various methods such as in-vitro release study, % yield, drug entrapment efficiency, pH of the prepared formulation. The prepared system was also characterized by FTIR spectrophotometer to identify the drug-excipients interaction. The maximum entrapment efficiency of pharmacosomes was found to be 90%. The main aim of this study was to develop and characterized a vesicular drug carrier system for topical delivery of Mefenamic Acid to overcome the problem related with oral route.

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References

Bangham AD, et al. The action of steroids and streptolysin S on the permeability of phospholipid structures to cation. J MolBiol. 1965; 13: 238.

Biju SS, et al. Vesicular System: An overview. Indian J. Pharm Sci. 2009; 71(4): 421-427.

Bombardelliet, et al. Phospholipid-Polyphenol complexes: A new concept in skincare ingredients. Cosm toil. 1991; 106(3): 69-76.

MJ Poznansky, RL Juliano. Biological approaches to the controlled delivery of drugs: A critical review, Pharmacological Reviews. 1984; 36: 277-336.

Vaizoglu O, et al. Pharmacosome: a novel drug delivery system, 1996, Acta Pharm Suec. 1996; 23: 163-172.

MO Vaizoglu, PP Speiser. Pharmacosomes- A Novel Drug Delivery System. Acta Pharmaceutica Suecica. 1986; 23: 163-172.

Jain NK, Advances in controlled and novel drug delivery system, Edn 4, Vol. I, CBS Publishers and Distributers, New Delhi. 2008; 276.

Ugochukwu AE, Nnedimkpa OJ, Rita NO. Preparation and characterization of Tolterodine tartrate proniosomes, Universal Journal of Pharmaceutical Research. 2017; 2(2): 1-3.

Tanu Goyal et al. Pharmacosomes: Opening new doors for Drug Delivery, International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4: 25-29.

Durgun Me, Algin Yapar E. A critical step for the cosmetic industry: scale-up. Universal Journal of Pharmaceutical Research. 2021; 6(3): 77-82.

Jitendra Patel et al. A Review on Pharmacosomes as a Novel Vesicular Drug Delivery System” , World journal of pharmaceutical research. 2012; 1: 456-469.

A Ping et al. Preparation and In Vivo Behavior of DidanosinePharmacosomes in Rats, Journal of Chinese Pharmaceutical Sciences. 2005; 3: 227-235.

Algin Yapar E, Şahiner A, Kara Ba, Tuna Yildirim S, Halat E, Bala R, Sindhu Rk. Evaluation of multifunctionality in cosmetics. Universal Journal of Pharmaceutical Research. 2021; 6(3): 50-54.

Afreen Uzmaet al. Pharmacosomes and Emulsomes: An Emerging Novel Vesicular Drug Delivery System. Global journal of anesthesia & pain medicine. July 2020; 287- 296.

Nweje-Anyalowu Paul C, Anyalogbu Ernest AA, White Alalibo Jim. Design and evaluation of chronotherapeutic pulsatile drug delivery system of Cilnidipine. Universal Journal of Pharmaceutical Research. 2017; 2(5): 15-18.

Pinnamaneni Bhanu Prasad. Machine Vision Systems and Image Processing with Applications”, Journal of Innovation in Computer Science and Emgineering. 2013; 3(1): 1-4.

Edrees WHA, Abdullah QYAM, AL-Kaf AG, Naji KM. A review on comparative study between the physicochemical and biological processes for paracetamol degradation. Universal Journal of Pharmaceutical Research. 2017; 2(2): 32-41.

DwiUtamiet al. Formation & Characterization of mefenamic acid- Nicotinamide Cocrystal during Co- milling based on X-ray Powder Diffraction Analysis. Journal of applied Pharmaceutical Science. October 2016; 6(10): 075-081.

Sunday OS. Colon-targeted drug delivery systems: design, trends and approaches. Universal Journal of Pharmaceutical Research. 2017; 2(4): 46-50.

Gurleen Kaur, Deepti, Kapil Kumar, Deepak Teotia. Preparation and Characterization of Floating Alginate Beads Of Lafutidine As A Gastroretentive Dosage Form, International Journal of Pharmaceutical Sciences and Research. 2020; 11(7): 2752-2760.

Peter OI, Ifeoma UC. Development and evaluation of Albendazole microcapsule for colonic drug delivery system. Universal Journal of Pharmaceutical Research. 2017; 2(2): 4-7.

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Published

2021-09-30

How to Cite

Kaur, G. ., Negi, K. ., Kumar, K. ., & Teotia, D. . (2021). Development and evaluation of Pharmacosome formulations of Mefenamic acid. GSC Biological and Pharmaceutical Sciences, 16(3), 229–234. https://doi.org/10.30574/gscbps.2021.16.3.0286

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