A comprehensive review on spanules: A novel drug delivery system

Tanushi dr; Aparna  Joshi; Dipti  Khairiya; Deepak  Teotia

doi:10.30574/gscbps.2022.18.1.0372

Authors

Tanushi dr Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
Aparna Joshi Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
Dipti Khairiya Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
Deepak Teotia Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.

DOI:

https://doi.org/10.30574/gscbps.2022.18.1.0372

Keywords:

Spanules, Hard gelatin capsule, Immediate drug release, Novel drug delivery system

Abstract

Spanules are considered one of the most advantageous drug delivery systems. Multi-drug regimen is the key benefit of Spanules (capsules having granules.) Spanules are constructed for the release of API (Drug) at different rates and times. The first immediate /slow-release pattern gives an initial drug release which is followed by drug release at a constant rate for an extended time.This will result in constantdrugsbeing available for a long time of period. This doses form is useful to overcome repeated drug dosing.

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References

Maurya R, Dr. Sharma PK, Malviya R. A Review on Controlled Drug Release Formulation: Spanules. 2014; 5(3):78-81.

Gurleen Kaur*, AshutoshBadola and SomyaSah, Research Article: World Journal of Pharmacy and Pharmaceutical Sciences. 5(6): 584-590.

ALGIN YAPAR E, BESKAN U, KARAVANA SY. A recent overview of locally administered topical otic dosage forms. Universal Journal of Pharmaceutical Research. 2019; 4(4): 39-42.

Sumedh N. Moharil, Dr. Shivshankar D. Mhaske, Mahesh B. Narkhede, and Assessmentof Controlled Release Formulation for Different Drug inSpanules: Research Article: World Journal Of Pharmacy And Pharmaceutical Sciences. 6(11): 908-916.

Rahi N, Kumar K. Nanosponges: a new era of versatile drug delivery system. Universal Journal of Pharmaceutical Research. 2017; 2(3): 30-33.

Jeffrey Blumberg B, Regan L Bailey, Cornelia M. Ulrich,the Evolving Role of Multivitamin Supplement Use among Adults in the Age of Personalized Nutrition.

KPreeta, Chugh, Lhamo Y. An Assessment of vitamin Supplements in the Indian Market: Indian Journal of Pharmaceutical Sciences. 2012.

Nutrition: Classification of Vitamins and Minerals, University of Hawai’I at Manoa Food Science and Human Nutrition Program, “vitamin: Introduction”,CC BY – NC 4.0.

Chigbo UJ, Ugochukwu AE, John DF. Dendrimers: a novel tool for drug delivery and targeting. Universal Journal of Pharmaceutical Research. 2017; 2(3): 34-40.

G Sirichandana, P Ashok kumar, Kulkarni SV, Formulation and Evaluation of Sustained Release Pellets of Domeperidone: International Journal of Drug Development and research. 2015.

AL-Adhami IAA, Al-Shamahy HA, Al-Meeril AM. Plasma ferritin and hepcidin levels in patients with type 2 diabetes mellitus. Universal Journal of Pharmaceutical Research. 2019; 4(1): 1-6.

HadiMohd Abdul, Raghavendra Rao NG. Novel Technologies in Formulations: An Overview. World Journal of Pharmaceutical Research. 2012; 1(3): 427.

Kuentz M, Rothenhauser B, Rothlisberger D. Time domain 1H NMR as a new method to monitor softening of gelatine and HPMC capsule shells, Drug Development and Industrial Pharmacy. 2006; 32(10): 1165-73.

Al-kaf AGA, Othman AM. Pharmacosomes: an Updated review, Universal Journal of Pharmaceutical Research. 2017; 2(1): 30-33.

Subrahmanyam CVS. A Textbook of Biopharmaceutics and Pharmacokinetics- Concepts and Applications. VallabhPrakashan. Controlled Drug Delivery Systems. 2009; 239.

Leon Lachman, Herbert A. Liberman, Joseph L. Kang, The Theory and Practice of Industrial Pharmacy, Third Edition, Varghese Publishing House, Bombay, Sustained Release Dosage Forms. 418-419.

Sunday OS. Colon-targeted drug delivery systems: design, trends and approaches. Universal Journal of Pharmaceutical Research. 2017; 2(4): 46-50.

Subrahmanyam CVS. A Textbook of Biopharmaceutics and Pharmacokinetics- Concepts and Applications. VallabhPrakashan. Controlled Drug Delivery Systems. 2009; 239.

Mathur P, Mathur CK, Mathur K. Oral drug delivery of insulin in diabetes mellitus: an attractive alternate to overcome invasive route. Universal Journal of Pharmaceutical Research. 2018; 3(6): 45-48.

Leon Lachman, Herbert A. Liberman, Joseph L. Kang, The Theory and Practice of Industrial Pharmacy, Third Edition, Varghese Publishing House, Bombay, Sustained Release Dosage Forms. 418-419.

Umar S, Onyekachi MK. Development and evaluation of transdermal gel of Lornoxicam. Universal Journal of Pharmaceutical Research. 2017; 2(1): 15-18.

Mohd Abdul Hadi, Raghavendra Rao NG. Novel Technologies in Formulations: An Overview. World Journal of Pharmaceutical Research. 2012; 1(3): 452.

ChughIsha, Seth Nimrata, Rana AC, Gupta Surbhi. Oral Sustained Drug Delivery System; an Overview. International Research Journal of Pharmacy. 2012; 3(5): 60.