61-year-old man with intestinal amyloidosis: A case report

Stefania Erra; Luca Zambello; Alessia Frigeri; Luca Michele De; Valentina Caminiti

doi:10.30574/gscbps.2020.11.3.0164

Authors

Stefania Erra Surgical Pathology Department, Santo Spirito Hospital, Casale Monferrato, Viale Giolitti 2, Italy.
Luca Zambello Surgical Pathology Department, Santo Spirito Hospital, Casale Monferrato, Viale Giolitti 2, Italy.
Alessia Frigeri Surgical Pathology Department, Santo Spirito Hospital, Casale Monferrato, Viale Giolitti 2, Italy.
Luca Michele De Surgical Pathology Department, Santo Spirito Hospital, Casale Monferrato, Viale Giolitti 2, Italy.
Valentina Caminiti Surgical Pathology Department, Santo Spirito Hospital, Casale Monferrato, Viale Giolitti 2, Italy.

DOI:

https://doi.org/10.30574/gscbps.2020.11.3.0164

Keywords:

Amyloidosis, Protein deposition, Colon, Monoclonal immunoglobulin

Abstract

Gastrointestinal amyloidosis (GIA), a protein deposition disorder, represents a complex common pathway that encompasses multiple etiologies and presentations. It is characterized by accumulation of insoluble extracellular protein fragments that have been rendered resistant to digestion. The most common form of systemic amyloidosis in the Western world is AL, in which the fibrils derive from monoclonal immunoglobulin light chains. Its incidence is approximately 10 cases / million / year with an average age at diagnosis of around 60 years. Herein, we report a case of 61-year-old man with colic AL amyloidosis.

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