Eclipta prostrata (L.) L. (uses and bioactivities)

Marina  Silalahi

doi:10.30574/gscbps.2022.18.1.0371

Authors

Marina Silalahi Prodi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kristen Indonesia. Jl. Mayjen Sutoyo, No. 2 Cawang, Jakarta Timur.

DOI:

https://doi.org/10.30574/gscbps.2022.18.1.0371

Keywords:

Eclipta prostrate, Anti-cancer, Anti-oxidant, Bioactivities

Abstract

Eclipta prostrata has been long used by humans as traditional medicine and hair fertilizer. This study aims to explain the relationship between utilization and bioactivity of E. prostrata. The method used is a literature review of articles published online on Google Scholar using the keywords E. prostrata, uses E. prostrata, and bioactivity of E. prostrata. Ethnobotanically, E. prostrata is used to treat liver disorders, liver tonic, respiratory disorders (asthma, cough), hepatitis, snake venom poisoning, and gastritis. In the field of beauty E. prostrata is used to nourish hair and treat baldness. The E. prostrata has bioactivity to treat neurodegeneration, asthma, anti-cancer, overcoming baldness, anti-diabetes mellitus, anti-oxidant, anti-inflammatory, anti-microbial, hepatoprotective, anti-osteoporosis, and anti-hypercholesterolemia. The bioactivity of E. prostrata is related to the content of its secondary metabolite compounds. Echinocystic acid and ecclalbasaponin II from E. prostrata are associated with anti-cancer activity.

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References

Han L, E Liu, A Kojo, J Zhao, W Li, Y Zhang, T Wang, X Gao. Qualitative and quantitative analysis of Eclipta prostrata L. by LC/MS. Hindawi Publishing Corporation. Scientific World Journal. 2015.

Gani AMS, DN Devi. Antioxidant activity of methanolic extract of Eclipta prostrata (L.)L. International Journal of Phytopharmacy. 2015; 5(2): 21-24.

de Freitas Morel LJ, BC de Azevedo, F Carmona, S Helen, T Contini, AM Teles, FS Ramalho, BW Bertoni, Sde Castro França, M de Carvalho Borges, AMS Pereira. A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. Journal of Ethnopharmacology. 2017; 198: 226-234.

Han L, E Liu, A Kojo, J Zhao, W Li, Y Zhang, T Wang, X Gao. Qualitative and quantitative analysis of Eclipta prostrata L. by LC/MS. Hindawi Publishing Corporation Scientific World Journal. 2015.

Chung IM, G Rajakumar, JH Lee, SH Kim, M Thiruvengadam. Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata. Appl Microbiol Biotechnol. 2017; 101: 5247-5257.

Lee CS, JA Kang, GY Kim, GR Kim. A study on the effect of Eclipta prostrata extract and mts on the improvement of scalp health and prevention of hair loss for workers in their 20s and 30s. Medico-legal Update. 2020; 20(1): 1850-1857.

Jaisin Y, P Ratanachamnong, S Prachayasittikul, R Watanapokasin, C Kuanpradit. Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Science Asia. 2016; 42: 259-265.

Sharma S, Richa, Harsimran. Phytochemical and anatomical screening of Eclipta prostrata L. An important medicinal herb from Chandigarh. Journal of Medicinal Plants Studies. 2017; 5(2): 255-258.

Sharma OP. Plant Taxonomy. Tata Mc Grow Hill Publishing Co. Ltd. New Delhi, India. 2004; 312-318.

Tzonev R. Eclipta prostrata (Asteraceae): a new alien species for the Bulgarian flora. Phytologia Balcanica. 2007; 13(1): 79-80.

Khanna VG, K Kannabiran. Anticancer-cytotoxic activity of saponins isolated from the leaves of Gymnema sylvestre and Eclipta prostrata on HeLa cells. International Journal of Green Pharmacy. 2009.

Lirdprapamongkol K, JP Kramb, D Chokchaichamnankit, C Srisomsap, R Surarit, M Sila-Asna, A Bunyaratvej, G Dannhardt and J Svasti. 2008. Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. 2008; 22: 363-368.

Cherdtrakulkiat R, S Boonpangrak, R Pingaew, S Prachayasittikul, S Ruchirawat, V Prachayasittikul. 2015. Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn. Journal of Applied Pharmaceutical Science. 2015; 5(03): 046-050.

Lee MK, NR Ha, H Yang, SH Sung, GH Kim, YC Kim. Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells. Phytomedicine. 2007.

Lee KH, D Choi, SI Jeong, SJ Kim, CH Lee, HS Seo, HS Jeong. Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5, Pharmaceutical Biology. 2018; 57(1): 105-111.

Rahman MS, MZ Rahman, B Begum, R Chowdhury, SN Islam, MA Rashid. Antidiabetic principle from Eclipta prostrata. Lat. Am. J. Pharm. 2011; 30(8): 1656-60.

Chan CF, WY Huang, HY Guo, and BR Wang. Potent Antioxidative and UVB Protective Effect of Water Extract of Eclipta prostrata L. Hindawi Publishing Corporation. Scientific World Journal. 2014.

Lee SH, IJ Jung, H Jang. The antioxidative effect of Eclipta prostrata L. extract on cultured nih3t3 fibroblasts injured by manganese-induced cytotoxicity. Biomedical Science Letters. 2018; 24(4): 357-364.

Lee HY. Enhancement of skin anti-inflammatory activities of Eclipta prostrata l. from the ultrasonic extraction process. Appl. Sci. 2017; 7: 1-10.

Arunachalam G, N Subramanian, GP Pazhani, V Ravichandran. Anti-inflammatory activity of methanolic extract of Eclipta prostrata L. (Astearaceae). African Journal of Pharmacy and Pharmacology. 2009; 3(3): 097-100.

Cuong TT, GH Diem, TT Doan, NQ Huy, N Phuong, HT Hung. Wedelolactone from Vietnamese Eclipta prostrata (L) L. protected zymosan-induced shock in mice. Iranian Journal of Pharmaceutical Research. 2018; 17(2): 653-660.

Karthikumar S, K Vigneswari, K Jegatheesan. Screening of antibacterial and antioxidant activities of leaves of Eclipta prostrata (L). Scientific Research and Essay. 2007; 2(4): 101-104.

Khanna VG, K Kannabiran. Antimicrobial activity of saponin fractions of the leaves of Gymnema sylvestre and Eclipta prostrata. World J Microbiol Biotechnol. 2008; 24: 2737–2740.

Chang KM, GH Kim. Constituents of the essential oil from Eclipta prostrata L. J Food Sci Nut. 2009; 14: 168-171.

Lin XH, YB Wu, S Lin, JW Zeng, PY Zeng and JZ Wu. Effects of volatile components and ethanolic extract from Eclipta prostrata on proliferation and differentiation of primary osteoblasts. Molecules. 2010; 15; 241-250.

Deng Y, W Kang, J Zhao, G Liu, M Zhao. Osteoprotective effect of echinocystic acid, a triterpone component from Eclipta prostrata, in ovariectomy-induced osteoporotic rats. PloS ONE. 2015; 10(8): e0136572.

Lee MK, NR Ha, H Yang, SH Sung and YC Kim. Stimulatory Constituents of Eclipta prostrata on mouse osteoblast differentiation. Phytother. Res. 2009; 23: 129-131.

Sahoo S, S Singh, M Dash, S Jena, A Sahoo, S Nayak, B Kar. Electron ionization based detection of volatile constituents of aerial parts of Eclipta prostrata (Linn.) by one dimensional gas chromatography and mass spectrometry. Journal of Essential Oil Bearing Plants. 2020.

Kim DI, SH Lee, JH Choi, HS Lillehoj, MH Yu, GS Lee. The butanol fraction of Eclipta prostrata (Linn) effectively reduces serum lipid levels and improves antioxidant activities in CD rats. Nutrition Research. 2008; 28: 550-554.